Genes from the TAS1R and TAS2R Families of Taste Receptors: Looking for Signatures of Their Adaptive Role in Human Evolution

• Tipo: Artigo em Revista Científica Internacional
• Data: 2018

Autores

Alvarez, L (Autor) Outra; Marques, PI (Autor) Outra; Gusmao, L (Autor) Outra; Amorim, A (Autor) FCUP; Seixas, S (Autor) Outra; Prata, MJ (Autor) FCUP; Valente, C (Autor) Outra

Revista

Título: Genome Biology and Evolution

Vol. 10

Páginas: 1139-1152

ISSN: 1759-6653

Editora: Oxford University Press

Indexação

ISI Web of Knowledge - 13 Citações

Scopus - 14 Citações

Outras Informações

ID Authenticus: P-00P-HJ5

DOI: 10.1093/gbe/evy071

Abstract (EN): Taste perception is crucial in monitoring food intake and, hence, is thought to play a significant role in human evolution. To gain insights into possible adaptive signatures in genes encoding bitter, sweet, and umami taste receptors, we surveyed the available sequence variation data from the 1000 Genomes Project Phase 3 for TAS1R (TAS1R1-3) and TAS2R (TAS2R16 and TAS2R38) families. Our study demonstrated that genes from these two families have experienced contrasting evolutionary histories: While TAS1R1 and TAS1R3 showed worldwide evidence of positive selection, probably correlated with improved umami and sweet perception, the patterns of variation displayed by TAS2R 16 and TAS2R38 were more consistent with scenarios of balancing selection that possibly conferred a heterozygous advantage associated with better capacity to perceive a wide range of bitter compounds. In TAS2R16, such adaptive events appear to have occurred restrictively in mainland Africa, whereas the strongest evidence in TAS2R38 was detected in Europe. Despite plausible associations between taste perception and the TAS1R and TAS2R selective signatures, we cannot discount other biological mechanisms as driving the evolutionary trajectories of those TAS1R and TAS2R members, especially given recent findings of taste receptors behaving as the products of pleiotropic genes involved in many functions outside the gustatory system.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 14