Etiopathogenesis of oncocytomas

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2017

Autores

Correia, M (Autor) Outra; Pinheiro, P (Autor) Outra; Batista, R (Autor) Outra; Soares, P (Autor) FMUP; Sobrinho Simoes, M (Autor) Outra; Maximo, V (Autor) FMUP

Revista

Título: Seminars in Cancer Biology

Vol. 47

Páginas: 82-94

ISSN: 1044-579X

Editora: Elsevier

Indexação

ISI Web of Knowledge - 7 Citações

Scopus - 9 Citações

Outras Informações

ID Authenticus: P-00N-BC2

DOI: 10.1016/j.semcancer.2017.06.014

Abstract (EN): Oncocytomas are distinct tumors characterized by an abnormal accumulation of defective and (most probably) dysfunctional mitochondria in cell cytoplasm of such tumors. This particular phenotype has been studied for the last decades and the clarification of the etiopathogenic causes are still needed. Several mechanisms involved in the formation and maintenance of oncocytomas are accepted as reasonable causes, but the relevance and contribution of each one for oncocytic transformation may depend on different cancer etiopathogenic contexts. In this review, we describe the current knowledge of the etiopathogenic events that may lead to oncocytic transformation and discuss their contribution for tumor progression and mitochondrial accumulation.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 13