Therapeutic Strategies for Alzheimer's and Parkinson's Diseases by Means of Drug Delivery Systems

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2016

Autores

Cunha, S (Autor) Outra; Maria Helena Amaral (Autor) FFUP; Sousa Lobo, JMS (Autor) Outra; Silva, AC (Autor) Outra

Revista

Título: Current Medicinal Chemistry

Vol. 23

Páginas: 3618-3631

ISSN: 0929-8673

Editora: Bentham

Indexação

ISI Web of Knowledge - 16 Citações

Scopus - 17 Citações

Outras Informações

ID Authenticus: P-00M-7EX

DOI: 10.2174/0929867323666160824162401

Abstract (EN): Alzheimer's and Parkinson's diseases are prevalent neurodegenerative disorders worldwide, which are essentially related to aging. Within the remarkable era of nanomedicine, nowadays several delivery systems have been suggested to improve the treatment of these disorders, namely, liposomes, micelles, nanoparticles (polymeric, lipid, metallic and inorganic), exosomes, dendrimers and fullerenes. The advantage that has been claimed to these delivery systems is that they facilitate the passage of drugs through the blood brain barrier (BBB), enabling targeting before body degradation, and increasing therapeutic efficacy, comparied to conventional pharmaceutical dosage forms. This review article provides a state of the art regarding the drug delivery systems that have been studied for the treatment of Alzheimer's and Parkinson's diseases. It begins with a brief description of the central nervous system (CNS) and the mechanisms involved in the development of these diseases. Later, some examples of drugs used in the treatment of these neurodegenerative diseases are presented, which are currently available in conventional pharmaceutical dosage forms, and in new drug delivery systems that are under development.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 14