From flamingo dance to (desirable) drug discovery: a nature-inspired approach

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2017

Autores

Sanchez Rodriguez, A (Autor) Outra; Perez Castillo, Y (Autor) Outra; Schurer, SC (Autor) Outra; Nicolotti, O (Autor) Outra; Mangiatordi, GF (Autor) Outra; Fernanda Borges (Autor) FCUP; Natalia N D S Cordeiro (Autor) FCUP; Tejera, E (Autor) Outra; Medina Franco, JL (Autor) Outra; Cruz Monteagudo, M (Autor) Outra

Revista

Título: Drug Discovery Today

Vol. 22

Páginas: 1489-1502

ISSN: 1359-6446

Editora: Elsevier

Indexação

ISI Web of Knowledge - 24 Citações

Scopus - 26 Citações

Outras Informações

ID Authenticus: P-00N-5D8

DOI: 10.1016/j.drudis.2017.05.008

Abstract (EN): The therapeutic effects of drugs are well known to result from their interaction with multiple intracellular targets. Accordingly, the pharma industry is currently moving from a reductionist approach based on a 'one-target fixation' to a holistic multitarget approach. However, many drug discovery practices are still procedural abstractions resulting from the attempt to understand and address the action of biologically active compounds while preventing adverse effects. Here, we discuss how drug discovery can benefit from the principles of evolutionary biology and report two real-life case studies. We do so by focusing on the desirability principle, and its many features and applications, such as machine learning-based multicriteria virtual screening.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 14