Size, Charge, and Stability of Fully Serine-Based Catanionic Vesicles: Towards Versatile Biocompatible Nanocarriers

• Tipo: Artigo em Revista Científica Internacional
• Data: 2015

Autores

Luisa L C Vale (Autor) FCUP; Eduardo F Marques (Autor) FCUP; Sandra G. Silva (Autor) Outra

Revista

Título: Chemistry - A European Journal

Vol. 21

Páginas: 4092-4101

ISSN: 0947-6539

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 25 Citações

Scopus - 0 Citações

Classificação Científica

CORDIS: Ciências Físicas > Química > Química orgânica ; Ciências Físicas > Química > Química física

FOS: Ciências exactas e naturais > Química

Outras Informações

ID Authenticus: P-00A-913

DOI: 10.1002/chem.201406111

Assunto: Size, Charge, and Stability of Fully Serine-Based Catanionic Vesicles: Towards Versatile Biocompatible Nanocarriers

Abstract (EN): Vesicles based on mixed cationic and anionic surfactants (catanionic vesicles) offer a number of advantageous colloidal features over conventional lipid-based vesicles, namely spontaneity in formation, long-term stability, and easy modulation of size and charge. If biocompatibility is added through rational design of the chemical components, the potential for biorelated applications further emerges. Here, we report for the first time on two catanionic vesicle systems in which both ionic amphiphiles are derivatized from the same amino acid-serine-with the goal of enhancing aggregate biocompatibility. Phase behavior maps for a mixture with chain length symmetry, 12Ser/12-12Ser, and another with asymmetry, 16Ser/8-8Ser, are presented, for which regions of vesicles, micelles, and coexisting aggregates are identified. For the asymmetric mixture, detailed phase behavior and microstructure characterization have been carried out based on surface tension, light microscopy, cryo-SEM, cryo-TEM, and dynamic light scattering analysis. Vesicles are found with tunable mean size, pH, and zeta potential. Changes in aggregate shape with varying composition and the effect of preparation methods and aging on vesicle features and stability have been investigated in detail. The results are discussed in the light of self-assembly models and related catanionic systems reported before. A versatile system of robust vesicles is thus presented for potential applications.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 10