Autoimmunity arising from bystander proliferation of T cells in an immune response model

• Tipo: Artigo em Revista Científica Internacional
• Data: 2011

Autores

Burroughs, NJ (Autor) Outra; Ferreira, M (Autor) Outra; Bruno M P M Oliveira (Autor) FCNAUP; Alberto A. Pinto (Autor) FCUP

Revista

Título: Mathematical and Computer Modelling

Vol. 53 Nº 7/8

Páginas: 1389-1393

ISSN: 0895-7177

Editora: Pergamon Press Ltd.

Indexação

ISI Web of Knowledge - 23 Citações

Scopus - 26 Citações

Outras Informações

ID Authenticus: P-002-SGJ

DOI: 10.1016/j.mcm.2010.01.020

Abstract (EN): We study a mathematical model of immune response by T cells where the regulatory T cells (Treg) inhibit interleukin 2 secretion. The bystander proliferation to an immune response is modelled. We consider an asymmetry reflecting that the difference between the growth and death rates can be higher for the active T cells and Tregs than for the inactive. This asymmetry leads to a better understanding of the bystander proliferation. An exposure to a pathogen results in an increased proliferation rate of the bystander T cells. If the population of the bystander T cells becomes large enough, autoimmunity can arise, eventually after a long transient period.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5