Importance of xeroderma pigmentosum group D polymorphisms in susceptibility to ovarian cancer

• Tipo: Artigo em Revista Científica Internacional
• Data: 2007

Autores

Sandra Costa (Autor) Outra; Daniela Pinto (Autor) Outra; Deolinda Pereira (Autor) Outra; Andre Vasconcelos (Autor) Outra; Carlos Afonso Lopes (Autor) Outra; Teresa Osorio (Autor) Outra; Carlos Lopes (Autor) ICBAS; Rui Medeiros (Autor) ICBAS

Revista

Título: Cancer Letters

Vol. 246

Páginas: 324-330

ISSN: 0304-3835

Editora: Elsevier

Indexação

ISI Web of Knowledge - 17 Citações

Scopus - 19 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina clínica

Outras Informações

ID Authenticus: P-004-BTZ

DOI: 10.1016/j.canlet.2006.03.014

Abstract (EN): The purpose of this study was to evaluate the role of XPD genotypes as genetic indicator of susceptibility to ovarian cancer. We have used a case-control study. We analysed DNA samples from 141 ovarian cancer patients and 202 control subjects, for three XPD polymorphisms using PCR-RFLP. We observed that Asn312Asn XPD genotype carriers have increased susceptibility of ovarian cancer (OR = 2.46 95% CI 1.20-5.06; P = 0.015). Furthermore, we found that carriers of Gln751Gln XPD genotype have an increased susceptibility of ovarian cancer (OR = 3.40 95% CI 1.61-7.15; P = 0.001). Asn312Asn and Gln751Gln are particularly associated with an early-stage of disease. Our results suggest an important role for Asn312Asn and Gln751Gln XPD polymorphisms in the susceptibility to ovarian cancer.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7