Dermic diffusion and stratum corneum: A state of the art review of mathematical models

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2014

Autores

Ana Couto (Autor) Outra; Ruben Fernandes (Autor) Outra; Natalia N S Cordeiro (Autor) FCUP; Sara S Reis (Autor) Outra; Rogerio T Ribeiro (Autor) Outra; Ana M Pessoa (Autor) Outra

Revista

Título: Journal of Controlled Release

Vol. 177

Páginas: 74-83

ISSN: 0168-3659

Editora: Elsevier

Indexação

ISI Web of Knowledge - 47 Citações

Scopus - 52 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Química

Outras Informações

ID Authenticus: P-009-6VZ

DOI: 10.1016/j.jconrel.2013.12.005

Abstract (EN): Transdermal biotechnologies are an ever increasing field of interest, due to the medical and pharmaceutical applications that they underlie. There are several mathematical models at use that permit a more inclusive vision of pure experimental data and even allow practical extrapolation for new dermal diffusion methodologies. However, they grasp a complex variety of theories and assumptions that allocate their use for specific situations. Models based on Fick's First Law found better use in contexts where scaled particle theory Models would be extensive in time-span but the reciprocal is also true, as context of transdermal diffusion of particular active compounds changes. This article reviews extensively the various theoretical methodologies for studying dermic diffusion in the rate limiting dermic barrier, the stratum corneum, and systematizes its characteristics, their proper context of application, advantages and limitations, as well as future perspectives.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 10