Prognostic biomarkers in thyroid cancer

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2014

Autores

Paula Soares (Autor) FMUP; Ricardo Celestino (Autor) Outra; Miguel Melo (Autor) Outra; Elsa Fonseca (Autor) Outra; Manuel Sobrinho Simoes (Autor) Outra

Revista

Título: Virchows Archiv

Vol. 464

Páginas: 333-346

ISSN: 0945-6317

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 40 Citações

Scopus - 44 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

Outras Informações

ID Authenticus: P-009-BP2

DOI: 10.1007/s00428-013-1521-2

Abstract (EN): Thyroid carcinomas represent a challenging problem from the prognostic standpoint. Despite an overall good prognosis of the most frequent endocrine malignancy, 10-15 % of papillary thyroid carcinomas (PTCs) turn refractory to radioactive iodine therapy. The increased incidence of thyroid cancer has led to the search for solid prognostic biomarkers that predict the behaviour of these tumours. Clinical and histopathological prognostic factors remain the only safe elements to be used for diagnosis and prognosis of patients with thyroid tumours. Despite the huge amount of genetic information of thyroid tumours, very few new markers revealed diagnostic or prognostic value per se. BRAF mutation can have some value if associated to other clinico-pathological parameters, or in the particular setting of iodine refractory tumours. Others can prove interesting in the future as predictive biomarkers of therapeutic response, but more studies are needed to confirm these potential biomarkers.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 14