The role of angiotensin II in hypertension due to adenosine receptors blockade

• Tipo: Artigo em Revista Científica Internacional
• Data: 2002

Autores

Morato, M (Autor) FFUP; Sousa, T (Autor) Outra; Guimaraes, S (Autor) Outra; Moura, D (Autor) FMUP; Albino Teixeira, A (Autor) FMUP

Revista

Título: European Journal of Pharmacology

Vol. 455

Páginas: 135-141

ISSN: 0014-2999

Editora: Elsevier

Indexação

ISI Web of Knowledge - 16 Citações

Scopus - 15 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

Outras Informações

ID Authenticus: P-000-MBW

DOI: 10.1016/s0014-2999(02)02587-6

Abstract (EN): The renin-angiotensin system may be involved in hypertension induced by adenosine receptors blockade with 1,3-dipropyl-8-sulfophenylxanthine (DPSPX). Contractions of the mesenteric vasculature to angiotensin II, noradrenaline and potassium chloride were studied in DPSPX-induced hypertension. Male Wistar rats received infusions of saline or DPSPX (90 mug kg(-1) h(-1), i.p.) for 3 or 7 days. Blood pressure was determined by the tail-cuff method. On days 3 or 14, concentration-response curves were obtained on mesenteric arteries and veins. Plasma angiotensin II levels, measured by radioimmunoassay, were higher in DPSPX-hypertensive rats. The maximum contractile effect of angiotensin II was lower in vessels from DPSPX-hypertensive rats while that for noradrenaline was higher. Potassium chloride-induced contractions were larger in veins from DPSPX-hypertensive rats but similar in arteries, when compared with control rats. We conclude that raised angiotensin II levels and altered vascular reactivity are consistent with a renin-angiotensin-mediated hypertension.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7