Impairment of T Cell Function in Parasitic Infections

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2014

Autores

Vasco Rodrigues (Autor) Outra; Anabela Cordeiro da Silva (Autor) FFUP; Mireille Laforge (Autor) Outra; Ali Ouaissi (Autor) Outra; Khadija Akharid (Autor) Outra; Ricardo Silvestre (Autor) Outra; Jerome Estaquier (Autor) Outra

Revista

Título: PLoS Neglected Tropical Diseases

Vol. 8

Página Final: e2567

ISSN: 1935-2727

Editora: Public Library of Science

Indexação

ISI Web of Knowledge - 37 Citações

Scopus - 53 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Ciências da saúde

Outras Informações

ID Authenticus: P-009-KHM

DOI: 10.1371/journal.pntd.0002567

Abstract (EN): In mammals subverted as hosts by protozoan parasites, the latter and/or the agonists they release are detected and processed by sensors displayed by many distinct immune cell lineages, in a tissue(s)-dependent context. Focusing on the T lymphocyte lineage, we review our present understanding on its transient or durable functional impairment over the course of the developmental program of the intracellular parasites Leishmania spp., Plasmodium spp., Toxoplasma gondii, and Trypanosoma cruzi in their mammalian hosts. Strategies employed by protozoa to down-regulate T lymphocyte function may act at the initial moment of naive T cell priming, rendering T cells anergic or unresponsive throughout infection, or later, exhausting T cells due to antigen persistence. Furthermore, by exploiting host feedback mechanisms aimed at maintaining immune homeostasis, parasites can enhance T cell apoptosis. We will discuss how infections with prominent intracellular protozoan parasites lead to a general down-regulation of T cell function through T cell anergy and exhaustion, accompanied by apoptosis, and ultimately allowing pathogen persistence.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 10