New Insights on the Biophysical Interaction of Resveratrol with Biomembrane Models: Relevance for Its Biological Effects

• Tipo: Artigo em Revista Científica Internacional
• Data: 2015

Autores

Neves, AR (Autor) Outra; Nunes, C (Autor) Outra; Reis, S (Autor) FFUP

Revista

Título: Journal of Physical Chemistry B

Vol. 119

Páginas: 11664-11672

ISSN: 1520-6106

Editora: American Chemical Society

Indexação

ISI Web of Knowledge - 15 Citações

Scopus - 27 Citações

Outras Informações

ID Authenticus: P-00G-MDZ

DOI: 10.1021/acs.jpcb.5b05419

Abstract (EN): Resveratrol has been widely studied because of its pleiotropic effects in cancer therapy, neuroprotection, and cardioprotection. It is believed that the interaction of resveratrol with biological membranes may play a key role in its therapeutic activity. The capacity of resveratrol to partition into lipid bilayers, its possible location within the membrane, and the influence of this compound on the membrane fluidity were investigated using membrane mimetic systems composed of egg L-alpha-phosphatidylcholine (EPC), cholesterol (CHOL), and sphingomyelin (SM). The results showed that resveratrol has greater affinity for the EPC bilayers than for EPC:CHOL [4:1] and EPC:CHOL:SM [1:1:1] membrane models. The increased difficulty in penetrating tight packed membranes is also demonstrated by fluorescence quenching of probes and by fluorescence anisotropy measurements. Resveratrol may be involved in the regulation of cell membrane fluidity, thereby contributing for cell homeostasis.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 9