In situ gelling systems: a strategy to improve the bioavailability of ophthalmic pharmaceutical formulations

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2014

Autores

Hugo Almeida (Autor) Outra; Maria Helena Amaral (Autor) FFUP; Paulo Lobao (Autor) FFUP; Jose Manuel S Sousa Lobo (Autor) Outra

Revista

Título: Drug Discovery Today

Vol. 19

Páginas: 400-412

ISSN: 1359-6446

Editora: Elsevier

Indexação

ISI Web of Knowledge - 133 Citações

Scopus - 160 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

Outras Informações

ID Authenticus: P-009-CS7

DOI: 10.1016/j.drudis.2013.10.001

Abstract (EN): The low therapeutic efficacy exhibited by conventional ophthalmic solutions owing to precorneal elimination of the drug, drainage by gravity, nasolacrimal drainage, conjunctival absorption, and the absence of controlled release and of bioadhesive properties, can be overcome by the use of in situ gelling systems. The combination in the same formulation of different in situ gelling polymers with different stimuli-responsiveness mechanisms exploiting the unique physicochemical characteristics of the ocular tissues is one such strategy that has produced improved results compared with conventional systems. As we discuss here, the recent use of biodegradable and biocompatible polymers in colloidal carrier systems has proved to be the most effective strategy, resulting in the exponential increase of the bioavailability of the ophthalmic drugs.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 13