Concise Overview of Glypromate Neuropeptide Research: From Chemistry to Pharmacological Applications in Neurosciences

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2023

Autores

Silva-Reis, SC (Autor) Outra; Sampaio-Dias, IE (Autor) Outra; Costa, VM (Autor) Outra; Correia, XC (Autor) Outra; Costa-Almeida, HF (Autor) Outra; Garcia-Mera, X (Autor) Outra; Rodriguez Borges, JE (Autor) FCUP

Revista

Título: Acs Chemical Neuroscience

Vol. 14

Páginas: 554-572

ISSN: 1948-7193

Editora: American Chemical Society

Indexação

ISI Web of Knowledge - 3 Citações

Scopus

Outras Informações

ID Authenticus: P-00X-X1J

DOI: 10.1021/acschemneuro.2c00675

Abstract (EN): Neurodegenerative diseases of the central nervous system (CNS) pose a serious health concern worldwide, with a particular incidence in developed countries as a result of life expectancy increase and the absence of restorative treatments. Presently, treatments for these neurological conditions are focused on managing the symptoms and/or slowing down their progression. As so, the research on novel neuroprotective drugs is of high interest. Glypromate (glycyl-L-prolyl-L-glutamic acid, also known as GPE), an endogenous small peptide widespread in the brain, holds great promise to tackle neurodegenerative diseases such as Parkinson's, Alzheimer's, and Huntington's, s well as other CNS-related disorders like Rett and Down's syndromes. However, the limited pharmacokinetic properties of Glypromate hinder its clinical application. As such, intense research has been devoted to leveraging the pharmacokinetic profile of this neuropeptide. This review aims to offer an updated perspective on Glypromate research by exploring the vast array of chemical derivatizations of more than 100 analogs described in the literature over the past two decades. The collection and discussion of the most relevant structure-activity relationships will hopefully guide the discovery of new Glypromate-based neuroprotective drugs.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 19