The perpetual movements of anaphase

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2010

Autores

Helder Maiato (Autor) FMUP; Lince Faria, M (Autor) Outra

Revista

Título: Cellular and Molecular Life Sciences

Vol. 67

Páginas: 2251-2269

ISSN: 1420-682X

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 33 Citações

Scopus - 36 Citações

Outras Informações

ID Authenticus: P-003-53K

DOI: 10.1007/s00018-010-0327-5

Abstract (EN): One of the most extraordinary events in the lifetime of a cell is the coordinated separation of sister chromatids during cell division. This is truly the essence of the entire mitotic process and the reason for the most profound morphological changes in cytoskeleton and nuclear organization that a cell may ever experience. It all occurs within a very short time window known as "anaphase", as if the cell had spent the rest of its existence getting ready for this moment in an ultimate act of survival. And there is a good reason for this: no space for mistakes. Problems in the distribution of chromosomes during cell division have been correlated with aneuploidy, a common feature observed in cancers and several birth defects, and the main cause of spontaneous abortion in humans. In this paper, we critically review the mechanisms of anaphase chromosome motion that resisted the scrutiny of more than 100 years of research, as part of a tribute to the pioneering work of Miguel Mota.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 19