Time-dependent genetic effects on gene expression implicate aging processes

• Tipo: Artigo em Revista Científica Internacional
• Data: 2017

Autores

Bryois, J (Autor) Outra; Buil, A (Autor) Outra; Ferreira, PG (Autor) Outra; Panousis, NI (Autor) Outra; Brown, AA (Autor) Outra; Viñuela, A (Autor) Outra; Planchon, A (Autor) Outra; Bielser, D (Autor) Outra; Small, K (Autor) Outra; Spector, T (Autor) Outra; Dermitzakis, ET (Autor) Outra

Revista

Título: Genome Research

Vol. 27

Páginas: 545-552

ISSN: 1088-9051

Editora: Cold Spring Harbor Laboratory Press

Indexação

Scopus - 18 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Ciências da computação e da informação

CORDIS: Ciências Naturais > Ciências biológicas > Biologia > Biologia computacional

FOS: Ciências exactas e naturais > Ciências biológicas

Outras Informações

ID Authenticus: P-00Q-55F

DOI: 10.1101/gr.207688.116

Abstract (EN): Gene expression is dependent on genetic and environmental factors. In the last decade, a large body of research has significantly improved our understanding of the genetic architecture of gene expression. However, it remains unclear whether genetic effects on gene expression remain stable over time. Here, we show, using longitudinal whole-blood gene expression data from a twin cohort, that the genetic architecture of a subset of genes is unstable over time. In addition, we identified 2213 genes differentially expressed across time points that we linked with aging within and across studies. Interestingly, we discovered that most differentially expressed genes were affected by a subset of 77 putative causal genes. Finally, we observed that putative causal genes and down-regulated genes were affected by a loss of genetic control between time points. Taken together, our data suggest that instability in the genetic architecture of a subset of genes could lead to widespread effects on the transcriptome with an aging signature. ©2017 Bryois et al.

Idioma: Inglês

Tipo (Avaliação Docente): Científica