Mitotic cell-cycle progression is regulated by CPEB1 and CPEB4-dependent translational control

• Tipo: Artigo em Revista Científica Internacional
• Data: 2010

Autores

Novoa, I (Autor) Outra; Gallego, J (Autor) Outra; Ferreira, PG (Autor) Outra; Mendez, R (Autor) Outra

Revista

Título: Nature Cell Biology

Vol. 12

Páginas: 447-U82

ISSN: 1465-7392

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 109 Citações

Scopus - 113 Citações

Classificação Científica

CORDIS: Ciências Naturais > Ciências biológicas > Biologia > Biologia molecular ; Ciências Naturais > Ciências biológicas > Biologia > Biologia computacional

FOS: Ciências exactas e naturais > Ciências biológicas ; Ciências exactas e naturais > Ciências da computação e da informação

Outras Informações

ID Authenticus: P-009-FDR

DOI: 10.1038/ncb2046

Abstract (EN): Meiotic and early-embryonic cell divisions in vertebrates take place in the absence of transcription and rely on the translational regulation of stored maternal messenger RNAs. Most of these mRNAs are regulated by the cytoplasmic-polyadenylation-element-binding protein (CPEB), which mediates translational activation and repression through cytoplasmic changes in their poly(A) tail length. It was unknown whether translational regulation by cytoplasmic polyadenylation and CPEB can also regulate mRNAs at specific points of mitotic cell-cycle divisions. Here we show that CPEB-mediated post-transcriptional regulation by phase-specific changes in poly(A) tail length is required for cell proliferation and specifically for entry into M phase in mitotically dividing cells. This translational control is mediated by two members of the CPEB family of proteins, CPEB1 and CPEB4. We conclude that regulation of poly(A) tail length is not only required to compensate for the lack of transcription in specialized cell divisions but also acts as a general mechanism to control mitosis.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 19