Long Pentraxin 3 as a Broader Biomarker for Multiple Risk Factors in End-Stage Renal Disease: Association with All-Cause Mortality

• Tipo: Artigo em Revista Científica Internacional
• Data: 2019

Autores

Valente, MJ (Autor) Outra; Rocha, S (Autor) Outra; Coimbra, S (Autor) Outra; Cristina Catarino (Autor) FFUP; Rocha Pereira, P (Autor) Outra; Bronze da Rocha, E (Autor) FFUP; José Oliveira (Autor) FMUP; Madureira, J (Autor) Outra; Fernandes, JC (Autor) Outra; do Sameiro Faria, M (Autor) Outra; Miranda, V (Autor) Outra; Belo, L (Autor) FFUP; Alice Santos Silva (Autor) FFUP

Revista

Título: Mediators of Inflammation

Vol. 2019

Páginas: 1-12

ISSN: 0962-9351

Editora: Hindawi

Indexação

ISI Web of Knowledge - 8 Citações

Scopus - 9 Citações

Outras Informações

ID Authenticus: P-00Q-SZN

DOI: 10.1155/2019/3295725

Abstract (EN): Persistent inflammation in end-stage renal disease (ESRD) patients is known to underlie the progression of chronic kidney disease and to be associated with multiple risk factors including malnutrition, atherosclerosis, and cardiovascular disease (CVD). The acute-phase protein pentraxin 3 (PTX3) has a proven potential as a local inflammatory biomarker, but its clinical utility in ESRD remains unclear. Circulating levels of PTX3 and classical inflammatory mediators, including the clinical prototypical C-reactive protein (CRP), were assessed in 246 ESRD patients on dialysis and analysed in relation to the lipid profile, adipokine levels, and nutritional, cardiac, and renal fibrosis markers. Occurrence of deaths was recorded for the following year. Contrarily to the classical inflammatory markers, PTX3 levels were negatively correlated with nutritional markers and associated with a less atherogenic lipid profile. Levels of the cardiac and renal fibrosis markers and of the oxidized LDL/LDL-C ratio were found to be independent determinants of PTX3 concentration. When comparing inflammatory mediators, the increase in the PTX3 levels was the only predictor of all-cause mortality in dialysis patients in a survival model adjusted to all markers under study, other than the inflammatory ones, besides common confounding factors in dialysis. Data support the clinical applicability of PTX3 as a broader inflammatory biomarker than the classical ones, presenting a close association with inflammation, malnutrition, CVD, and renal fibrosis and a great potential to predict all-cause mortality in dialysis patients. The pleiotropic character of PTX3 may be of clinical relevance, and it could be targeted to ameliorate the high morbidity and mortality associated with ESRD.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 12