Ecotoxicological evaluation of gilthead seabream (Sparus aurata) exposed to the antibiotic oxytetracycline using a multibiomarker approach

• Tipo: Artigo em Revista Científica Internacional
• Data: 2018

Autores

Rodrigues, S (Autor) Outra; Antunes, SC (Autor) FCUP; Correia, AT (Autor) Outra; Nunes, B (Autor) Outra

Revista

Título: Marine Environmental Research

Vol. 141

Páginas: 233-246

ISSN: 0141-1136

Editora: Elsevier

Indexação

ISI Web of Knowledge - 22 Citações

Scopus - 24 Citações

Outras Informações

ID Authenticus: P-00P-N30

DOI: 10.1016/j.marenvres.2018.09.009

Abstract (EN): Oxytetracycline (OTC) is an antibiotic widely used in human and veterinary medicines. Since the primary toxicity occurs mainly at molecular/biochemical levels, the study of different biological responses corresponds to a sensitive and crucial approach. The aim of the present study was to assess the toxic effects of OTC in gilthead seabream (Spares aurata) through the use of multibiomarkers and elucidate about the possible toxicological mechanisms involved. S. aurata were acutely (96 h: 0.04-400 mu g/L) and chronically (28 days: 0.0004-4 mu g/L) exposed to OTC. Detoxification, antioxidant defense, lipid peroxidation, genotoxicity, neurotransmission and energy metabolism biomarkers were evaluated. OTC impaired the detoxification pathways and caused peroxidative damage and genotoxicity. The relevance of the here-obtained data is high, since significant effects were recorded for levels already reported to occur in the wild, meaning that environmentally-exposed marine organisms (including those cultured at fish farms) are not completely exempt of risks posed by OTC.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 14