Regulatory T cell adjustment of quorum growth thresholds and the control of local immune responses

• Tipo: Artigo em Revista Científica Internacional
• Data: 2006

Autores

Burroughs, NJ (Autor) Outra; Bruno M P M Oliveira (Autor) FCNAUP; Alberto A. Pinto (Autor) FCUP

Revista

Título: Journal of Theoretical Biology

Vol. 241 Nº 1

Páginas: 134-141

ISSN: 0022-5193

Editora: Elsevier

Indexação

ISI Web of Knowledge - 49 Citações

ISI Web of Science

Scopus - 49 Citações

Pubmed / Medline

Classificação Científica

FOS: Ciências exactas e naturais > Matemática

CORDIS: Ciências Físicas > Matemática > Matemática aplicada

Outras Informações

ID Authenticus: P-004-JMQ

DOI: 10.1016/j.jtbi.2005.11.010

Abstract (EN): The consequences of regulatory T cell (Treg) inhibition of interleukine 2 secretion is examined by mathematical modelling. We demonstrate that cytokine dependent growth exhibits a quorum T cell population threshold that determines if immune responses develop on activation. Secretion inhibition manipulates the growth dynamics and effectively increases the quorum threshold, i.e. to develop immune responses a higher number of T cells need to be activated. Thus Treg induced secretion inhibition can provide a mechanism for tissue specific regulation of the balance between suppression (control) and immune responses, a balance that can be varied at the local tissue level through the regulation of the local active Treg population size. However, nonspecific inhibition is prone to escape of initially controlled autoimmune T cells through cross reactivity to pathogens and bystander proliferation on unrelated immune responses.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8