Tissues Regeneration and Repair

Code:

M.BIO003

Acronym:

RRTE

Keywords
Classification	Keyword
OFICIAL	Biomedical Engineering

Instance: 2023/2024 - 1S

Active?	Yes
Responsible unit:	Department of Metallurgical and Materials Engineering
Course/CS Responsible:	Master in Bioengineering

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
M.BIO	49	Syllabus	1	-	6	52	162
MEB	11	Syllabus	1	-	6	52	162
			2

Teaching language

English

Objectives

This course will present the main strategies currently under development or either in clinical trials or in the market, to promote tissue regeneration and restoration of function. A wide range of applications, from the regeneration of the skin, musculoskeletal system and cardiovascular system, as well as emerging areas such as the regeneration of the nervous system, will be addressed.

Learning outcomes and competences

This course (curricular unit, UC) will present the foundational elements of Regenerative Medicine. Benefiting from the knowledge and skills acquired in other UCs, it provides a comprehensive and coherent set of concepts and tools used in this area of knowledge. Namely, strategies aimed at the development and / or manipulation of molecules, cells, tissues or organs in order to repair, replace or support body parts injured or disabled with a view to recovery of their function. It also promotes critical vision of the advantages and limitations of different techniques, as well as its adaptation to non-conventional scenarios.

The learning outcomes of the UC are:

• Evaluate the performance of current approaches in tissue repair and regeneration;
• Know the limitations of the different approaches and the physiological changes over time;
• Recognize and understand the reasons for clinical failure of different strategies;
• Understand and evaluate the best strategy for a given physiological system;
• Know the legislation, regulations and standards in force, associated with the development of a new medical device and its placement on the market;
• Plan characterization tests of regeneration strategies according to their intended application;
• Select and manipulate materials for a specific application in the human body;
• Critically evaluate the characteristics of new strategies and new medical devices presented by the manufacturing industry, by standardization institutes or referred to in scientific journals.

 

Working method

Presencial

Program

1. Introductory concepts

1.1. Introduction

1.2. Cells, tissues, organs, systems and organs

1.3. Bioreactors for Regenerative Medicine and Tissue Engineering

1.4. Biofabrication

 

2. Systems and tissues

2.1. Skin Regeneration and plastic and reconstructive surgery

2.2. Cardiovascular system

2.3. Musculoskeletal system

2.4. Nervous system

2.5. Organ building

 

3. Social, economical, ethical and regulatory issues

 

Lab sessions are planned with practical examples that will illustrate the concepts discussed in the lectures. The lab works includes: 

- Basic principles of cell culture

- Culture of cells

- Effect of surface chemistry on cell behaviour

- Cell culture in 3D matrices

 

Mandatory literature

ed. Clemens van Blitterswijk; Tissue engineering. ISBN: 978-0-12-370869-4
R. Ian Freshney; Culture of animal cells. ISBN: 978-0-470-52812-9

Complementary Bibliography

ed. Anthony Atala [et al.]; Foundations of regenerative medicine. ISBN: 978-0-12-375085-3
ed. Robert Lanza, Robert Langer, Joseph Vacanti; Principles of tissue engineering. ISBN: 978-0-12-370615-7
Edited by Buddy D. Ratner... [et al.]; Biomaterials science. ISBN: 0-12-582463-7
Frontiers in Tissue Engineering, Patrick CW Jr, Mikos AG e McIntire LV, 1998

Teaching methods and learning activities

a) General theoretical-practical classes will be based on the presentation of the themes of the course unit, along with the discussion of practical examples that illustrate the addressed methodologies and strategies;

b) Laboratory classes on themes of this course unit 

keywords

Health sciences > Ethics in health sciences
Technological sciences > Engineering > Biomedical enginnering
Technological sciences > Engineering > Biomaterial engineering
Health sciences > Medical sciences > Medicine

Evaluation Type

Distributed evaluation with final exam

Assessment Components

Designation	Weight (%)
Exame	70,00
Trabalho laboratorial	30,00
Total:	100,00

Amount of time allocated to each course unit

Designation	Time (hours)
Estudo autónomo	92,00
Frequência das aulas	42,00
Trabalho laboratorial	28,00
Total:	162,00

Eligibility for exams

Students are required to have an active role and to attend, at least, 75% of the practical classes and obtain a minimum classification of 10 out of 20 in the laboratory component.

Calculation formula of final grade

Final grade = theoretical component grade * 0.70 + lab sessions grade * 0.30

Theoretical grade = Grade of the exam.

Lab sessions grade = 0.25 * grade of the participation in the lab sessions + 0.50 * grade of test + + 0.25 * oral presentation of the work done by each group (poster)


Note: The evaluation test will have a duration of 45 min + 15 min of tolerance and will consist of a list of multiple choice / true or false questions.

A minimum of 10 out of 20, both in the written exam as well as in the lab Sessions component, is required for approval.

Special assessment (TE, DA, ...)

As specified by the rules applicable to Master in Bioengineering and Master in Biomedical Engineering.

Classification improvement

The grades of the laboratory component are final. The exam grade can be improved at times defined by the rules of Degree in Bioengineering and Master in Biomedical Engineering.