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Tissues Regeneration and Repair

Code: EBE0185     Acronym: RRTE

Classification Keyword
OFICIAL Biomedical Engineering

Instance: 2016/2017 - 1S Ícone do Moodle

Active? Yes
Responsible unit: Department of Metallurgical and Materials Engineering
Course/CS Responsible: Master in Bioengineering

Cycles of Study/Courses

Acronym No. of Students Study Plan Curricular Years Credits UCN Credits ECTS Contact hours Total Time
MEB 32 Syllabus 1 - 6 70 162
MIB 48 Syllabus 4 - 6 70 162

Teaching - Hours

Recitations: 3,00
Laboratory Practice: 2,00
Type Teacher Classes Hour
Recitations Totals 1 3,00
Pedro Lopes Granja 1,50
Ana Paula Gomes Moreira Pêgo 1,50
Laboratory Practice Totals 4 8,00
Isabel Maria Santana Ramos de Freitas Amaral 4,00
Marta de Sousa Laranjeira 4,00

Teaching language

Suitable for English-speaking students


This course will present the main strategies currently under development or either in clinical trials or in the market, to promote tissue regeneration and restoration of function. A wide range of applications, from the regeneration of the skin, musculoskeletal system and cardiovascular system, as well as emerging areas such as the regeneration of the nervous system, will be addressed.

Learning outcomes and competences

This course (curricular unit, UC) will present the foundational elements of Regenerative Medicine. Benefiting from the knowledge and skills acquired in other UCs, it provides a comprehensive and coherent set of concepts and tools used in this area of knowledge. Namely, strategies aimed at the development and / or manipulation of molecules, cells, tissues or organs in order to repair, replace or support body parts injured or disabled with a view to recovery of their function. It also promotes critical vision of the advantages and limitations of different techniques, as well as its adaptation to non-conventional scenarios.

Working method



1. Introductory concepts

1.1. Introduction

1.2. Cells, tissues, organs, systems and organs

1.3. Bioreactors for Regenerative Medicine and Tissue Engineering

1.4. Biofabrication


2. Systems and tissues

2.1. Skin Regeneration and plastic and reconstructive surgery

2.2. Cardiovascular system

2.3. Musculoskeletal system

2.4. Nervous system

2.5. Organ building


3. Social, economical, ethical and regulatory issues


Lab sessions are planned with practical examples that will illustrate the concepts discussed in the lectures. The lab works includes: 

- Basic principles of cell culture

- Culture of cells

- Effect of surface chemistry on cell behaviour

- Cell culture in 3D matrices


Mandatory literature

ed. Clemens van Blitterswijk; Tissue engineering. ISBN: 978-0-12-370869-4
R. Ian Freshney; Culture of animal cells. ISBN: 978-0-470-52812-9

Complementary Bibliography

ed. Anthony Atala [et al.]; Foundations of regenerative medicine. ISBN: 978-0-12-375085-3
ed. Robert Lanza, Robert Langer, Joseph Vacanti; Principles of tissue engineering. ISBN: 978-0-12-370615-7
Edited by Buddy D. Ratner... [et al.]; Biomaterials science. ISBN: 0-12-582463-7
Frontiers in Tissue Engineering, Patrick CW Jr, Mikos AG e McIntire LV, 1998

Teaching methods and learning activities

a) General theoretical-practical classes will be based on the presentation of the themes of the course unit, along with the discussion of practical examples that illustrate the addressed methodologies and strategies;

b) Laboratory classes on themes of this course unit 


Technological sciences > Engineering > Biomedical enginnering
Health sciences > Ethics in health sciences
Technological sciences > Engineering > Biomaterial engineering
Health sciences > Medical sciences > Medicine

Evaluation Type

Distributed evaluation with final exam

Assessment Components

Designation Weight (%)
Exame 70,00
Trabalho laboratorial 30,00
Total: 100,00

Eligibility for exams

Students are required to have an active role and to attend, at least, 75% of the practical classes and obtain a minimum classification of 10 out of 20 in the laboratory component.

Calculation formula of final grade

Final grade = theoretical component grade * 0.70 + lab sessions grade * 0.30

Theoretical grade = 0.10 * debate grade + 0.90 * grade of the exam.

Lab sessions grade = 0.25 * grade of the participation in the lab sessions + 0.40 * grade of test + 0.35 * note of the practical examination 

Note: The evaluation test will have a duration of 45 min + 15 min of tolerance and will consist of a list of multiple choice / true or false questions.

A minimum of 10 out of 20, both in the written exam as well as in the lab Sessions component, is required for approval.

Special assessment (TE, DA, ...)

As specified by the rules applicable to the Mestrado Integrado em Bioengenharia.

Classification improvement

The grades of the laboratory component and of the debates are final. The exam grade can be improved at times defined by the rules of the MSc in Bioengineering.
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