Process Engineering II

Code:

EBE0158

Acronym:

EPR2

Keywords
Classification	Keyword
OFICIAL	Biological Engineering

Instance: 2012/2013 - 1S

Active?	Yes
Course/CS Responsible:	Master in Bioengineering

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
MIB	17	Syllabus	4	-	6	56	162

Teaching language

Portuguese

Objectives

This course unit aims to:

-explain the fundamental concepts related to bioprocess engineering, namely the ones related to separation processes and economic analysis.
- develop students’ capacity to carry out a critical analysis and ways of solving design and operation problems, which occur in the above mentioned scientific domains.
- present some examples of molecular biotechnology and/or system biology problems, which were described and simplified by taking an engineering approach.
- encourage students to read both speciality books and scientific papers in English.
- promote teamwork.

Program

1. Introduction: Examples of separation processes in biotechnology used in industry and investigation. The importance of economic aspects in an industrial process.
2. Solid-liquid separation: Sedimentation; Centrifugation; Filtration. Filtration centrifuges
3. Other membrane processes: Ultrafiltration; Microfiltration; Inverted osmosis; Dialyses; Membrane characterization – materials, structure and porosity.
4. Separation processes with electrical field gradient: electrophoresis
5. Methods of cell rupture: physical; chemical; enzymatic; Osmotic shock
6. Chromatographic methods: liquid-liquid chromatography, high-pressure chromatography
7. Mass spectrometry of biomolecules
8. Cost analysis of bioprocesses. Industrial examples
9. Examples of application of concepts of bioengineering to molecular biotechnology and system biology: Hybridization of nucleic acids; Modelling and optimization of biological systems

Mandatory literature

Harrison, Roger G. 070; Bioseparations science and engineering. ISBN: 0-19-512340-9
Dorf, Richard C.; The engineering handbook. ISBN: 0-8493-8344-7

Teaching methods and learning activities

Theoretical-practical classes (2 hours/week) will be based on the presentation of theoretical concepts and application of the processes mentioned on the program. It will be analysed the fundamental theoretical concepts, it will be applied the necessary equations to calculate the phenomena which are being studied, as well as an explanation and resolution of problems.
The resolution of problems and the training involved have to be done outside class time. However, the professor will be available to answer students’ doubts in a time yet to be announced.

Evaluation Type

Distributed evaluation with final exam

Eligibility for exams

Attendance at classes

Calculation formula of final grade

Final Grade comprises two components:
1) Group assignment (25%): analysis and presentation of a scientific paper (maximum of three students in each group) related to the program.
2) Final Exam (75%): It covers the entire program (3h). Normal or recurso (resit) season.

Examinations or Special Assignments

See Final Grade

Special assessment (TE, DA, ...)

Not applicable

Classification improvement

Exam

Observations

Not applicable