Oncobiology

Code:

EBE0082

Acronym:

ONCO

Keywords
Classification	Keyword
OFICIAL	Molecular Biotechnology

Instance: 2012/2013 - 2S

Active?	Yes
E-learning page:	https://moodle.fe.up.pt/
Course/CS Responsible:	Master in Bioengineering

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
MIB	29	Syllabus	4	-	5	42	135

Teaching language

Portuguese

Objectives

Objectives
1. Understand the concept of cancer as an alteration of cell/ tissue growth and differentiation;
2. Recognize the major types of human cancer and its temporal evolution;
3. Identify the major steps of neoplastic development and the agents involved in this process;
4. Recognize the molecular basis / genetics underlying the process of tumorigenesis;
5. Recognize the process of tumorigenesis as the interaction between organism and environment;
6. Identify and understand the major hereditary conditions associated with cancer;
7. Identify the therapeutic strategies based on molecular characterization of tumors;
8. Understanding the need for a multidisciplinary approach in oncology.

Developing skills and learning outcomes
1. Acquire the essential concepts about the classification and epidemiological characteristics of major types of cancer;
2. Identify the main morphological characteristics of the most common types of human neoplasia;
3. Recognize cancer as a result of accumulation of genomic changes, based on the characteristics of the organism and its interaction with environmental agents;
4. Understand the key mechanisms underlying the process of tumorigenesis and its contribution to disease progression;
5. Identify the most frequent hereditary predisposition to cancer;
6. Understand the basic mechanisms of therapy directed at molecular targets;
7. Integrate the general concepts of Oncobiology in the major models human neoplasia;
8. Recognize the main fields and lines of research of Oncobiology and their potential impact on medical practice.

Program

1. Neoplasia: basic concepts and classification, methods of study;
2. Carcinogens: chemical, physical, biological;
3. The Biology of the neoplastic cell: transformation, growth and progression, mechanisms of invasion,angiogenesis and metastasis; interaction neoplasia / stroma, immunity and cancer, inflammation and cancer;
4. Cancer genomics as a disease: the historical evolution of concepts;
5. Molecular mechanisms of tumorigenesis and deregulation of the genes associated with cancer: chromosomal and genetic alterations underlying neoplastic growth;
6. Epigenetics and cancer: mechanisms of action and potential application to the development of cancer biomarkers;
7. Hereditary predisposition to cancer: mechanisms and main syndromes; molecular biology methodologies;
8. Clinical and multidisciplinary therapeutic approaches;
9. Targeted therapy;
10. Research in Oncology.

Mandatory literature

Robbins Basic Pathology, Vinay Kumar, Abul K. Abbas, Nelson Fausto, Richard N. Mitchell, 2007
The Molecular Basis of Cancer, John Mendelsohn, Peter M. Howley, Mark A. Israel, Joe W. Gray, Craig B. Thompson (eds.). 3rd Edition, 2008
The Genetic Basis of Human Cancer , Bert Vogelstein and Kenneth W. Kinzler (eds.). 2nd Edition, 2002

Teaching methods and learning activities

1. Theoretical: general exposition and discussion of programmatic issues, stimulating interaction between students and teachers and focusing on clinical relevance of the concepts and their applications current or potential
2. Theoretical and practical sessions: consolidation of the main concepts exposed in the theoretical sessions and displaying iconography relevant to each thematic area

Software

Plataforma de e-learning da UP - Moodle

keywords

Health sciences > Medical sciences > Medicine

Evaluation Type

Evaluation with final exam

Assessment Components

Description	Type	Time (hours)	Weight (%)	End date
Attendance (estimated)	Participação presencial	42,00
Final exam	Exame	1,50
	Total:	-	0,00

Amount of time allocated to each course unit

Description	Type	Time (hours)	End date
Self study	Estudo autónomo	91,5
	Total:	91,50

Eligibility for exams

Presence in 2/3 of the theoretical/practical sessions

Calculation formula of final grade

Final exam composed by multiple choice questions and questions for thematic development; Students are approved if their exam classification is equal or exceeds 9.45 / 20.

Examinations or Special Assignments

According the Standards for Evaluation and Pedagogical Orientation of the University of Porto

Special assessment (TE, DA, ...)

According the Standards for Evaluation and Pedagogical Orientation of the University of Porto

Classification improvement

Classification obtained in the examination