Bioengineering II

Code:

EQ0052

Acronym:

B II

Keywords
Classification	Keyword
OFICIAL	Opções Temáticas

Instance: 2009/2010 - 1S

Active?	Yes
Responsible unit:	Department of Chemical Engineering
Course/CS Responsible:	Master in Chemical Engineering

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
MIEQ	7	Syllabus	5	-	5	-

Teaching language

Portuguese

Objectives

To acquire with the necessary proficiency advanced knowledge regarding downstream strategies for biological products and also their approval and regulation. To develop expertise an analyzing industrial process diagrams and to use bioinformatic tools.

Program

1 – Biotechnology and bioproducts

2 – Introduction to downstream processing of biologicals

3 – Cell disruption
a) Mechanical metohds
b) Non- mechanical methods

4 – Solid-liquid separation
a) Sedimentation
b) Centrifugation
c) Conventional filtration
d) Membrane processes

5 - Cromatography
a) Gel filtration
b) Ionic exchange
c) Affinity
d) Hydrophobic interaction

6 - Extraction

7 - Precipitation and crystallization

8 - Solvent removal
a) Drying
b) Freeze-drying
c) Evaporation

9 – Product activity

10 - Regulation
a) Validation
b) Approval
c) Formulation

11 - Bioinformatic analysis

12 – Industrial process diagrams

13 – Simulation of downstream processes

Mandatory literature

Harrison, Roger G. 070; Bioseparations science and engineering. ISBN: 0-19-512340-9

Complementary Bibliography

Crommelin, Daan J. A. 340; Pharmaceutical biotechnology. ISBN: 0-415-28501-1
Filipe Mergulhão; Textos de apoio da disciplina, 2008
Wink, M. (ed); An introduction to molecular biotechnology, Wiley-VCH, 2006. ISBN: 3-527-31412-1

Teaching methods and learning activities

Oral teaching using the blackboard and slides. Selected classes will use PC's with specific simulation software and bioinformatic tools available on the web

Software

Office 2000

Evaluation Type

Distributed evaluation without final exam

Assessment Components

Description	Type	Time (hours)	Weight (%)	End date
Subject Classes	Participação presencial	72,00
	Total:	-	0,00

Eligibility for exams

According to the general rules

Calculation formula of final grade

Final classification is obtained by the following formula:

N = 0.4xTrab + 0.3xAp + 0.3xT

where,

Trab – group work grade
Ap – Oral presentation and discussion grade
T – Test grade

In order to be approved students must obtain grades above 8 (on a 0 to 20 scale) on all the components and the final grade (N) must be higher or equal to 10

Examinations or Special Assignments

Students will have to deliver a group work (set at the beginning of the semester) by December 10th. Some parts of this work will be done in the classes and a list of deliverables and their due dates will be posted.
Students will have to present their work and discuss it in class by December 3rd.
An evaluation test is scheduled for December 10th.

Special assessment (TE, DA, ...)

According to the general rules.

Classification improvement

It will be done during the resit period and only the grade obtained on the test can be improved.