Bioengineering II
Keywords |
Classification |
Keyword |
OFICIAL |
Opções Temáticas |
Instance: 2009/2010 - 1S
Cycles of Study/Courses
Acronym |
No. of Students |
Study Plan |
Curricular Years |
Credits UCN |
Credits ECTS |
Contact hours |
Total Time |
MIEQ |
7 |
Syllabus |
5 |
- |
5 |
- |
|
Teaching language
Portuguese
Objectives
To acquire with the necessary proficiency advanced knowledge regarding downstream strategies for biological products and also their approval and regulation. To develop expertise an analyzing industrial process diagrams and to use bioinformatic tools.
Program
1 – Biotechnology and bioproducts
2 – Introduction to downstream processing of biologicals
3 – Cell disruption
a) Mechanical metohds
b) Non- mechanical methods
4 – Solid-liquid separation
a) Sedimentation
b) Centrifugation
c) Conventional filtration
d) Membrane processes
5 - Cromatography
a) Gel filtration
b) Ionic exchange
c) Affinity
d) Hydrophobic interaction
6 - Extraction
7 - Precipitation and crystallization
8 - Solvent removal
a) Drying
b) Freeze-drying
c) Evaporation
9 – Product activity
10 - Regulation
a) Validation
b) Approval
c) Formulation
11 - Bioinformatic analysis
12 – Industrial process diagrams
13 – Simulation of downstream processes
Mandatory literature
Harrison, Roger G. 070;
Bioseparations science and engineering. ISBN: 0-19-512340-9
Complementary Bibliography
Crommelin, Daan J. A. 340;
Pharmaceutical biotechnology. ISBN: 0-415-28501-1
Filipe Mergulhão; Textos de apoio da disciplina, 2008
Wink, M. (ed); An introduction to molecular biotechnology, Wiley-VCH, 2006. ISBN: 3-527-31412-1
Teaching methods and learning activities
Oral teaching using the blackboard and slides. Selected classes will use PC's with specific simulation software and bioinformatic tools available on the web
Software
Office 2000
Evaluation Type
Distributed evaluation without final exam
Assessment Components
Description |
Type |
Time (hours) |
Weight (%) |
End date |
Subject Classes |
Participação presencial |
72,00 |
|
|
|
Total: |
- |
0,00 |
|
Eligibility for exams
According to the general rules
Calculation formula of final grade
Final classification is obtained by the following formula:
N = 0.4xTrab + 0.3xAp + 0.3xT
where,
Trab – group work grade
Ap – Oral presentation and discussion grade
T – Test grade
In order to be approved students must obtain grades above 8 (on a 0 to 20 scale) on all the components and the final grade (N) must be higher or equal to 10
Examinations or Special Assignments
Students will have to deliver a group work (set at the beginning of the semester) by December 10th. Some parts of this work will be done in the classes and a list of deliverables and their due dates will be posted.
Students will have to present their work and discuss it in class by December 3rd.
An evaluation test is scheduled for December 10th.
Special assessment (TE, DA, ...)
According to the general rules.
Classification improvement
It will be done during the resit period and only the grade obtained on the test can be improved.