Structure and Function of Proteins
Keywords |
Classification |
Keyword |
OFICIAL |
Molecular Biotechnology |
Instance: 2010/2011 - 2S
Cycles of Study/Courses
Acronym |
No. of Students |
Study Plan |
Curricular Years |
Credits UCN |
Credits ECTS |
Contact hours |
Total Time |
MIB |
13 |
Syllabus |
3 |
- |
5 |
42 |
135 |
Teaching language
Portuguese
Objectives
This course unit aims to relate protein structures to their biological role, by giving examples of proteins, which perform diverse biological functions.
This course unit also aims to develop students’ critical skills, by making them surveying and presenting recent scientific papers related to the various themes of this course unit.
Program
Methods of study of protein-ligand interactions
Proteolytic enzymes: apoptotic proteases: caspase, HIV-1 proteases; Protease-activated receptors
Membrane proteins: Structure and function and channel transporters
Receptors and lipoproteins metabolism
Signalization: main ways of signalization in inflammatory response and neurotrophin action
Pathogenic proteins: transthyretin as an example of amyloidogenesis: perspectives for upcoming therapeutic approaches; Pathologic conformations of prion protein; Molecular basis of some neurodegenerative diseases: Alzheimer, Parkinson, triplet diseases.
Teaching methods and learning activities
Classes will be based on the presentation of the program and bibliography selected from international scientific magazines.
Students will have to present scientific articles.
Evaluation Type
Distributed evaluation with final exam
Assessment Components
Description |
Type |
Time (hours) |
Weight (%) |
End date |
Attendance (estimated) |
Participação presencial |
0,00 |
|
|
|
Total: |
- |
0,00 |
|
Eligibility for exams
Students have to attend theoretical-practical classes and each student has to present a scientific article.
Calculation formula of final grade
Presentation of a seminar is worth 20% of the final grade.