Structure and Function of Proteins

Code:

EBE0073

Acronym:

EFPR

Keywords
Classification	Keyword
OFICIAL	Molecular Biotechnology

Instance: 2010/2011 - 2S

Active?	Yes
Course/CS Responsible:	Master in Bioengineering

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
MIB	13	Syllabus	3	-	5	42	135

Teaching language

Portuguese

Objectives

This course unit aims to relate protein structures to their biological role, by giving examples of proteins, which perform diverse biological functions.

This course unit also aims to develop students’ critical skills, by making them surveying and presenting recent scientific papers related to the various themes of this course unit.

Program

Methods of study of protein-ligand interactions
Proteolytic enzymes: apoptotic proteases: caspase, HIV-1 proteases; Protease-activated receptors
Membrane proteins: Structure and function and channel transporters
Receptors and lipoproteins metabolism
Signalization: main ways of signalization in inflammatory response and neurotrophin action

Pathogenic proteins: transthyretin as an example of amyloidogenesis: perspectives for upcoming therapeutic approaches; Pathologic conformations of prion protein; Molecular basis of some neurodegenerative diseases: Alzheimer, Parkinson, triplet diseases.

Teaching methods and learning activities

Classes will be based on the presentation of the program and bibliography selected from international scientific magazines.
Students will have to present scientific articles.

Evaluation Type

Distributed evaluation with final exam

Assessment Components

Description	Type	Time (hours)	Weight (%)	End date
Attendance (estimated)	Participação presencial	0,00
	Total:	-	0,00

Eligibility for exams

Students have to attend theoretical-practical classes and each student has to present a scientific article.

Calculation formula of final grade

Presentation of a seminar is worth 20% of the final grade.