Three new jatrophane-type diterpenes from Euphorbia pubescens

• Type: Article in International Scientific Journal
• Date: 2003

Authors

Valente, C (Author) Other; Ferreira, MJU (Author) Other; Abreu, PM (Author) Other; Pedro, M (Author) Other; Cerqueira, F (Author) Other; Nascimento, MSJ (Author) FFUP

Journal

Title: Planta Medica

Vol. 69

Pages: 361-366

ISSN: 0032-0943

Publisher: Thieme

Indexing

ISI Web of Knowledge - 20 Citations

Scopus - 18 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-000-H9J

DOI: 10.1055/s-2003-38875

Abstract (EN): Three new macrocyclic jatrophane diterpene polyesters, named pubescenes A (1), B (2), and C (3), and the known compounds indole-3-aldehyde and scopoletin have been isolated and characterised from the whole dried plant of Euphorbia pubescens. The structures of the new compounds were established by spectroscopic means including 2D-NMR techniques such as COSY, HMQC, HMBC and NOESY experiments. Compounds 1-3 were evaluated for their in vitro effect on the growth of three human cancer cell lines MCF-7 (breast), NCI-H460 (lung) and SF-268 (CNS) as well as for their capacity to interfere with the proliferation of human peripheral blood lymphocytes. They exhibited a moderate growth inhibitory effect on the cancer cell line NCI-H460. No effect was observed on the mitogenic response of human lymphocytes to PHA.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6