Natural Compounds with Cell Growth Inhibitory Activity in Human Tumor Cell Lines

• Type: Article in International Scientific Journal
• Date: 2013

Authors

Cristiane M Cazal (Author) Other; Kantima Choosang (Author) Other; Vanessa Gisele P Severino (Author) Other; Joao B Fernandes (Author) Other; Maria Fatima G F da Silva (Author) Other; Paulo C Vieira (Author) Other; Maria S J Nascimento (Author) FFUP; Gabriela M Almeida (Author) Other; Helena Vasconcelos, MH (Author) FFUP; Pannee Pakkong (Author) Other; Madalena M M Pinto (Author) FFUP

Journal

Title: Anti-Cancer Agents in Medicinal Chemistry

Vol. 13

Pages: 1582-1589

ISSN: 1871-5206

Publisher: Bentham Science

Indexing

ISI Web of Knowledge - 3 Citations

Scopus - 3 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-006-JBH

DOI: 10.2174/1871520613666131125122857

Abstract (EN): Twenty six compounds (coumarins, flavonoids and alkaloids) were evaluated for their ability to inhibit the growth of three human tumor cell lines: breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and melanoma (A375-C5). Three of them [3-hydroxyflavone (6), 2'-hydroxy-3,4,4', 5,6'-pentamethoxychalcone (11), Siderin (20)] were very potent in inhibiting all human tumor cell lines tested. The structure/activity relationship is discussed.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8