Effects of a prenyl-baicalein derivative on ER (+) MCF-7 and ER (-) MDA-MB-231 breast tumor cell lines

• Type: Article in International Scientific Journal
• Date: 2012

Authors

Marta Perro Neves (Author) Other; Ana Camoes (Author) Other; Maria de Sao Jose Nascimento (Author) FFUP; Honorina Cidade (Author) FFUP; Maria Emilia Sousa (Author) FFUP; Madalena Maria M Magalhaes Pinto (Author) FFUP

Journal

Title: Medicinal Chemistry Research

Vol. 21

Pages: 3154-3160

ISSN: 1054-2523

Publisher: Springer Nature

Indexing

ISI Proceedings

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-002-59B

DOI: 10.1007/s00044-011-9848-1

Abstract (EN): The effect of a prenyl-baicalein derivative in the DNA synthesis of the estrogen-dependent ER (+) MCF-7 and the estrogen-independent ER (-) MDA-MB-231 cell lines was evaluated using both complete and steroid-free medium. The results revealed a biphasic effect in DNA synthesis of ER (+) MCF-7 cells. Moreover, this prenylflavone seemed to reduce the estrogenic effect of 17 beta-estradiol and to increase the antiestrogenic effect of 4-hydroxytamoxifen and fluvestrant on the ER (+) MCF-7 cells.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7