Xanthones as inhibitors of growth of human cancer cell lines and their effects on the proliferation of human lymphocytes in vitro

• Type: Article in International Scientific Journal
• Date: 2002

Authors

Pedro, M (Author) Other; Cerqueira, F (Author) Other; Sousa, ME (Author) Other; Nascimento, MSJ (Author) FFUP; Pinto, M (Author) FFUP

Journal

Title: Bioorganic and Medicinal Chemistry

Vol. 10

Pages: 3725-3730

ISSN: 0968-0896

Publisher: Elsevier

Indexing

ISI Proceedings

ISI Web of Knowledge - 126 Citations

Scopus - 133 Citations

Scientific classification

FOS: Natural sciences > Chemical sciences

Other information

Authenticus ID: P-000-M4Y

DOI: 10.1016/s0968-0896(02)00379-6

Abstract (EN): Twenty-seven oxygenated xanthones have been assessed for their capacity to inhibit in vitro the growth of three human cancer cell lines, MCF-7 (breast cancer). TK-10 (renal cancer) and UACC-62 (melanoma). The effect of these xanthones on the proliferation of human T-lymphocytes was also evaluated. Differences on their potency towards the effect on the growth of the human cancer cell lines as well as on the proliferation of human T-lymphocytes can be ascribed to the nature and positions of the substituents on the xanthonic nucleus.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6