Cytotoxicity of prenylated xanthones and other constituents from the wood of Garcinia merguensis

• Type: Another Publication in an International Scientific Journal
• Date: 2008

Authors

Anake Kijjoa (Author) ICBAS; Maria Jose Gonzalez (Author) Other; Madalena M Pinto (Author) FFUP; Maria Sao Jose Nascimento (Author) FFUP; Nair Campos (Author) Other; Ing On Mondranondra (Author) Other; Artur M S Silva (Author) Other; Graham Eaton (Author) Other; Werner Herz (Author) Other

Journal

Title: Planta Medica

Vol. 74

Pages: 864-866

ISSN: 0032-0943

Publisher: Thieme

Indexing

ISI Web of Knowledge - 4 Citations

Scopus - 5 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-003-Z5W

DOI: 10.1055/s-2008-1074544

Abstract (EN): One new prenylated xanthone 5-farnesyltoxyloxanthone B (4), three known xanthones alpha-mangostin (1), rubraxanthone (2) and isocowanol (3) as well as (2E,6E,10E)-4 beta-hydroxy-3-methyl-5 beta-(3,7,11,15-tetramethylhexadeca-2,6,10-tetraenyl)-cyclo- hex-2-en-1-one (5) and 3,3,4-0-trimethylellagic acid were isolated from the wood of Garcinia merguensis Wight. The cytotoxic activities of compounds 1-5 were evaluated against the MCF-7, MDA-MB-231, NCI-H-460 and SF-268 cell lines with rubraxanthone 2 and 5 exhibiting the highest activity at 9.0 and 12.1 mu M, respectively, against MCF-7 cells.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 3