Increased oxidative stress in mesenteric artery from hypertensive rats with activation of the renin-angiotensin system

• Type: Article in International Conference Proceedings Book
• Date: 2004

Authors

Sousa, T (Author) Other; Morato, M (Author) FFUP; Pinho, D (Author) Other; Fernandes, E (Author) FFUP; Carvalho, F (Author) FFUP; Albino Teixeira, A (Author) FMUP

Conference proceedings International

Title: PROCEEDINGS OF THE 23RD EUROPEAN CONFERENCE ON MICROCIRCULATION

Pages: 137-140

23rd European Conference on Microcirculation

Lisbon, PORTUGAL, SEP 08-11, 2004

Indexing

ISI Web of Knowledge - 1 Citation

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

Other information

Authenticus ID: P-000-DFR

Abstract (EN): Chronic treatment of rats with the adenosine antagonist 1,3-dipropyl-8-sulfophenylxanthine (DPSPX) induces hypertension, vascular hyperplasia and hypertrophy and renin-angiotensin system activation. Since angiotensin II (Ang II) stimulates the production of reactive oxygen species (ROS), we aimed at evaluating the mesenteric artery activity of NADPH oxidase and glutathione peroxidase (GPx) in this hypertension. Sham and DPSPX (90 mug/kg/h, i.p., 7 days)-treated rats were used. Systolic blood pressure (SBP) was measured by the tail cuff method. Rats were sacrificed on day 14. Enzyme activities were evaluated by spectrophotometric methods. DPSPX treatment increased SBP, NADPH oxidase and GPX activities when compared to sham. We can conclude that DPSPX-induced hypertension is associated with increased vascular generation of ROS.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4