Unraveling the mechanism of the farnesyltransferase enzyme

• Type: Another Publication in an International Scientific Journal
• Date: 2005

Authors

Sousa, SF (Author) Other; Fernandes, PA (Author) FCUP; Ramos, MJ (Author) FCUP

Journal

Title: Journal of Biological Inorganic Chemistry

Vol. 10

Pages: 3-10

ISSN: 0949-8257

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 40 Citations

Scopus - 38 Citations

Scientific classification

FOS: Natural sciences > Chemical sciences

Other information

Authenticus ID: P-000-612

DOI: 10.1007/s00775-004-0612-6

Abstract (EN): Farnesyltransferase enzyme (FTase) is currently one of the most fascinating targets in cancer research. Studies in other areas, namely in the fight against parasites and viruses, have also led to very promising results. However, in spite of the thrilling achievements in the development of farnesyltransferase inhibitors (FTIs) over the past few years, the farnesylation mechanism remains, to some degree, a mystery. This review tries to shed some light on this puzzling enzyme by analyzing seven key mechanistic dilemmas, based on recent studies that have dramatically changed the way this enzyme is currently perceived.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8