Ribonucleotide Reductase: A Mechanistic Portrait of Substrate Analogues Inhibitors

• Type: Another Publication in an International Scientific Journal
• Date: 2010

Authors

Perez, MAS (Author) Other; Cerqueira, NMFSA (Author) FCUP; Fernandes, PA (Author) FCUP; Ramos, MJ (Author) FCUP

Journal

Title: Current Medicinal Chemistry

Vol. 17 No. 26

Pages: 2854-2872

ISSN: 0929-8673

Publisher: Bentham Science

Indexing

ISI Web of Knowledge - 12 Citations

Scopus - 13 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-003-378

DOI: 10.2174/092986710792065054

Abstract (EN): Ribonucleotide reductase (RNR) is the key enzyme in the biosynthesis of deoxyribonucleotides. Several different strategies for inactivation of RNRs have been reported, including the use of substrate analogues as mechanism-based inhibitors. This article undergoes a critical analysis on the current status of ribonucleotide reductase inhibitory mechanisms by substrate analogues highlighting experimental and theoretical/computational approaches. We have summarized a general portrait of the inhibitory mechanisms and classified the nucleoside analogue inhibitors in three main classes. The critical analysis undertaken will contribute in finding new and more effective ways of inhibiting RNR.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 19