Voltammetric insights in the transfer of ionizable drugs across biomimetic membranes - Recent achievements

• Type: Article in International Scientific Journal
• Date: 2007

Authors

Rubin Gulaboski (Author) Other; Fernanda Borges (Author) FFUP; Carlos M Pereira (Author) FCUP; Natalia N D S Cordeiro (Author) FCUP; Jorge Garrido (Author) Other; Fernando F Silva (Author) FCUP

Journal

Title: Combinatorial Chemistry & High Throughput Screening

Vol. 10

Pages: 514-526

ISSN: 1386-2073

Publisher: Bentham Science

Indexing

ISI Web of Knowledge - 18 Citations

Scopus - 19 Citations

Scientific classification

FOS: Natural sciences > Chemical sciences

Other information

Authenticus ID: P-004-8A1

DOI: 10.2174/138620707782152399

Abstract (EN): The latest results of voltammetric research on the ionic transfer process of ionisable drugs across bare and lipid-modified liquid-liquid interfaces are reviewed. In recent years, two voltammetric methods have been extensively applied to this purpose, i.e. the classical four electrode voltammetry at the interface between two immiscible electrolyte solutions, and the "three-phase electrode." Thus, a brief background of the methodologies and some successful examples of their application are highlighted in this work. Particular attention is given to the ionic transfer kinetics and to the electro-chemical characterization of the drug-membrane interactions between the ionized drugs and lipid-modified interfaces. Future trends in this area are also mentioned in connection with high-throughput assessment of ADMET properties of drugs.

Language: English

Type (Professor's evaluation): Scientific