Effects of interleukin-12 in the long-term protection conferred by a Mycobacterium avium subunit vaccine

• Type: Article in International Scientific Journal
• Date: 2000

Authors

Silva, RA (Author) Other; Pais, TF (Author) Other; Appelberg, R (Author) ICBAS

Journal

Title: Scandinavian Journal of Immunology

Vol. 52

Pages: 531-533

ISSN: 0300-9475

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 7 Citations

Scopus - 9 Citations

Pubmed / Medline

Scientific classification

FOS: Medical and Health sciences > Basic medicine

CORDIS: Health sciences > Medical sciences > Medicine > Infections

Other information

Authenticus ID: P-000-YD8

DOI: 10.1046/j.1365-3083.2000.00816.x

Abstract (EN): The effects of the addition of recombinant interleukin (IL)-12 to a mycobacterial subunit vaccine were analyzed in terms of the longevity of the protective immunity generated. BALB/c mice were immunized with culture filtrate proteins from Mycobacterium avium with dimethyl-dioctadecilammonium bromide (DDA) as an adjuvant. This subunit vaccine induced protection against a challenge by M. avium which lasted for at least 6 months while waning with time until 1 year postvaccination. Whereas the addition of IL-12 enhanced the initial protective efficacy of this subunit vaccine during the first 6 months, it accelerated the loss of protective efficacy observed at 1 year postvaccination. These data confirm the adjuvant properties of IL-12 in vaccines against mycobacteria and raise the possibility of late counter-protective untoward effects.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 3