Granuloma necrosis during Mycobacterium avium infection does not require tumor necrosis factor

• Type: Article in International Scientific Journal
• Date: 2004

Authors

Florido, M (Author) Other; Appelberg, R (Author) ICBAS

Journal

Title: Infection and Immunity

Vol. 72

Pages: 6139-6141

ISSN: 0019-9567

Publisher: American Society for Microbiology

Indexing

ISI Web of Knowledge - 15 Citations

Scopus - 14 Citations

Pubmed / Medline

Scientific classification

FOS: Medical and Health sciences > Basic medicine

CORDIS: Health sciences > Medical sciences > Medicine > Infections

Other information

Authenticus ID: P-000-89G

DOI: 10.1128/iai.72.10.6139-6141.2004

Abstract (EN): The infection of tumor necrosis factor (TNF)-deficient mice with low doses of the virulent Mycobacterium avium strain 25291 led to the appearance of necrotic granulomas at 93 days of infection, i.e., sooner than necrotic granulomas appeared in C57BL/6 animals. Additionally, TNF-deficient mice exhibited higher mycobacterial loads in the infected organs, had extremely exacerbated gamma interferon responses as evaluated in the sera of infected animals, and showed reduced survival. Thus, TNF is not required for granuloma necrosis.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 3