Clozapine-induced palilalia?

• Type: Article in International Scientific Journal
• Date: 2011

Authors

Jacinto Azevedo (Author) FMUP; Rui Lopes (Author) FMUP; Rosário Curral (Author) FMUP; Manuel Esteves (Author) FMUP; Rui Coelho (Author) FMUP; António Roma Torres (Author) FMUP

Journal

Title: Acta Neuropsychiatrica

ISSN: 0924-2708

Publisher: Cambridge University Press

Indexing

ISI Proceedings

Scientific classification

FOS: Medical and Health sciences > Other medical sciences

Other information

Abstract (EN): Introduction: Palilalia is an acquired speech disorder characterised by involuntary and spontaneous repetition of words or phrases two or more times in a row. It can occur in a variety of disorders including postencephalic parkinsonism, pseudobulbar palsy, schizophrenia, Gilles de la Tourette syndrome and others. Clinical Case: We describe a case of a 28-year-old man with refractory schizophrenia that developed palilalia with 300 mg of clozapine. In the patient evaluation we found unspecific alterations in the electroencephalogram, with normal blood tests and cerebral magnetic resonance imaging. Palilalia disappeared with lowering doses of clozapine. Discussion: The appearance of palilalia induced by clozapine is a rare pharmacologic side-effect which physicians should be familiarised with when evaluating this symptom presentation.

Language: English

Type (Professor's evaluation): Scientific