Release profile of ibuprofen in beta-cyclodextrin complexes from two different solid dosage forms

• Type: Article in International Scientific Journal
• Date: 2012

Authors

salustio, pj (Author) Other; feio, g (Author) Other; figueirinhas, jl (Author) Other; cabral-marques, hm (Author) Other; costa, pc (Author) FFUP; pinto, jf (Author) Other

Journal

Title: Powder Technology

Vol. 221

Pages: 245-251

ISSN: 0032-5910

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 4 Citations

Scopus - 6 Citations

Other information

Authenticus ID: P-002-AQC

DOI: 10.1016/j.powtec.2012.01.008

Abstract (EN): The objective of this work was to develop solid dosage forms using powders containing inclusion complexes (ibuprofen with beta-cyclodextrin) which were used to produce tablets (direct compression without additional excipients) and pellets (extrusion/spheronization) from wet mass containing 40% (w/w) of microcrystalline cellulose. The pellets also demonstrated that during preparation of the wet mass, the inclusion process occurred in a same yield that when pre-complexation was used. The particles characteristics were evaluated after being obtained through different complexation methods. The results showed that the tensile strength and profile dissolution were as expected for both dosage forms. Tablets containing inclusion complexes showed higher solubility when compared with a reference formulation and with two commercial formulations. The ibuprofen released from the two pellets formulations didn't show relevant differences between them. The drug released was analyzed considering different dissolution parameters. The advantages of these new methodologies can be summarized as: (a) tablets were produced at a lower cost for the total process; and (b) in the pellet's preparation there was no need of the previous complexation method resulting in a decrease in time and energy required.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7