CIPROFLOXACIN AND NORFLOXACIN SPECTROPHOTOMETRIC DETERMINATION IN A FULLY AUTOMATED MULTI-PUMPING FLOW SYSTEM

• Type: Article in International Scientific Journal
• Date: 2011

Authors

Helena H R Amorim (Author) Other; Karine L Marques (Author) Other; Joao L M Santos (Author) FFUP; Jose L F C Lima (Author) FFUP

Journal

Title: Analytical Letters

Vol. 44 No. 4

Pages: 2074-2084

ISSN: 0003-2719

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 5 Citations

ISI Web of Science

Scopus - 8 Citations

Scientific classification

FOS: Natural sciences > Chemical sciences

CORDIS: Physical sciences > Chemistry > Analytical chemistry

Other information

Authenticus ID: P-002-X9T

DOI: 10.1080/00032719.2010.546018

Resumo (PT): A flow-based methodology for the spectrophotometric determination of ciprofloxacin and norfloxacin, based on the oxidation with N-bromosuccinimide in acidic medium, was developed. The proposed procedure was implemented in a multi-pumping flow system, which provided excellent mixing conditions due to the pulsed flow produced by solenoid micro-pumps actuation, resulting on a sensitive, simple, fast, and versatile analytical method. Linear calibration plots were obtained for ciprofloxacin and norfloxacin concentrations ranging from 5 to 70 mg L−1 with an R.S.D < 2.2% (n = 10). Detection limits (3σ) were 0.27 mg L−1 and 0.99 mg L−1 for norfloxacin and ciprofloxacin, respectively. <br> <br> <a target="_blank" href="http://www.tandfonline.com/doi/abs/10.1080/00032719.2010.546018 "> Texto integral </a> <br> <br>

Abstract (EN): A flow-based methodology for the spectrophotometric determination of ciprofloxacin and norfloxacin, based on the oxidation with N-bromosuccinimide in acidic medium, was developed. The proposed procedure was implemented in a multi-pumping flow system, which provided excellent mixing conditions due to the pulsed flow produced by solenoid micro-pumps actuation, resulting on a sensitive, simple, fast, and versatile analytical method. Linear calibration plots were obtained for ciprofloxacin and norfloxacin concentrations ranging from 5 to 70 mg L(-1) with an R.S.D < 2.2% (n=10). Detection limits (3 sigma) were 0.27 mg L(-1) and 0.99 mg L(-1) for norfloxacin and ciprofloxacin, respectively.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 11