Sequential injection lab-on-valve procedure for the determination of amantadine using potentiometric methods

• Type: Article in International Scientific Journal
• Date: 2007

Authors

Amorim, CG (Author) Other; Araujo, AN (Author) FFUP; Montenegro, MCBSM (Author) FFUP; Silva, VL (Author) Other

Journal

Title: Electroanalysis

Vol. 19 No. 21

Pages: 2227-2233

ISSN: 1040-0397

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 18 Citations

ISI Web of Science

Scopus - 20 Citations

Scientific classification

FOS: Natural sciences > Chemical sciences

CORDIS: Health sciences

Other information

Authenticus ID: P-004-6F9

DOI: 10.1002/elan.200703973

Resumo (PT): Amantadine potentiometric detectors were developed, evaluated and incorporated in a SIA-LOV manifold in order to accomplish the control of pharmaceutical formulations and urine. The electrodes incorporate -cyclodextrin as ionophore, dibutyl phthalate or 2-fluorophenyl 2-nitrophenyl ether as plasticizers and potassium tetrakis[3,5-bis-(trifluoromethyl)phenyl]borate (KTFPB) as cationic additive. The slope increased from 61.2 to 63.8 mV decade-1 and the practical limit of detection from 2.6×10-6 mol L-1 to 2.5×10-5 mol L-1 when the plasticizer was changed from 2-fluorophenyl 2-nitrophenyl ether to dibutyl phthalate. When incorporated in the flow-manifold the membranes composed by dibutyl phthalate or with 2-fluorophenyl 2-nitrophenyl ether presented slopes and a practical limit of detection of 69.8 mV decade-1 and 1.5×10-4 mol L-1 or 73.7 mV decade-1 and 5.4×10-5 mol L-1, respectively. The electrode presented stable responses for over a year, and were highly selective concerning the representative species of the two sample matrices assayed as interferents. Comparison of obtained results with those provided by reference methods and recovery assays, revealed adequate accuracy for control assays. <br> <br> Keywords Lab-on-valve • Ion selective electrodes • Potentiometry • Amantadine • Cyclodextrin <br> <a target="_blank" href="http://www3.interscience.wiley.com/journal/116324534/abstract"> Texto integral</a> <br> <br>

Abstract (EN): Amantadine potentiometric detectors were developed, evaluated and incorporated in a SIA-LOV manifold in order to accomplish the control of pharmaceutical formulations and urine. The electrodes incorporate a-cyclodextrin as ionophore, dibutyl phthalate or 2-fluorophenyl 2-nitrophenyl ether as plasticizers and potassium tetrakis[3,5-bis-(trifluoromethyl)phenyl]borate (KTFPB) as cationic additive. The slope increased from 61.2 to 63.8 mV decade(-1) and the practical limit of detection from 2.6 x 10(-6) mol L-1 to 2.5 x 10(-5) mol L-1 when the plasticizer was changed from 2-fluorophenyl 2-nitrophenyl ether to dibutyl phthalate. When incorporated in the flow-manifold the membranes composed by dibutyl phthalate or with 2-fluorophenyl 2-nitrophenyl ether presented slopes and a practical limit of detection of 69.8 mV decade(-1) and 1.5 x 10(-4) mol L-1 or 73.7 mV decade(-1) and 5.4 x 10(-5) mol L-1, respectively. The electrode presented stable responses for over a year, and were highly selective concerning the representative species of the two sample matrices assayed as interferents. Comparison of obtained results with those provided by reference methods and recovery assays, revealed adequate accuracy for control assays.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7