Toxicity Mechanisms of Gadolinium and Gadolinium-Based Contrast Agents-A Review

• Type: Another Publication in an International Scientific Journal
• Date: 2024

Authors

Coimbra, S (Author) Other; Rocha, S (Author) Other; Sousa, NR (Author) Other; Cristina Catarino (Author) FFUP; Belo, L (Author) FFUP; Bronze da Rocha, E (Author) FFUP; Valente, MJ (Author) Other; Santos-Silva, A (Author) Other

Journal

Title: International Journal Of Molecular Sciences

Vol. 25

Final page: 4071

ISSN: 1661-6596

Publisher: MDPI

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Other information

Authenticus ID: P-010-9XP

DOI: 10.3390/ijms25074071

Abstract (EN): Gadolinium-based contrast agents (GBCAs) have been used for more than 30 years to improve magnetic resonance imaging, a crucial tool for medical diagnosis and treatment monitoring across multiple clinical settings. Studies have shown that exposure to GBCAs is associated with gadolinium release and tissue deposition that may cause short- and long-term toxicity in several organs, including the kidney, the main excretion organ of most GBCAs. Considering the increasing prevalence of chronic kidney disease worldwide and that most of the complications following GBCA exposure are associated with renal dysfunction, the mechanisms underlying GBCA toxicity, especially renal toxicity, are particularly important. A better understanding of the gadolinium mechanisms of toxicity may contribute to clarify the safety and/or potential risks associated with the use of GBCAs. In this work, a review of the recent literature concerning gadolinium and GBCA mechanisms of toxicity was performed.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 22