Abstract (EN):
Improving the aqueous solubility of poorly soluble hydrophobiccompounds is a topic of great interest to the pharmaceutical, chemical,and food industries. The poor solubility of these compounds in waterposes a challenge in developing sustainable processes for their extraction,separation, and formulation. Therefore, in this study, the use ashydrotropes of biobased solvents such as & gamma;-valerolactone (GVL),Cyrene, ethyl lactate, and alkanediols (1,2-propanediol, 1,5-pentanediol,and 1,6-hexanediol) to improve the solubility of two model compounds(syringic acid and ferulic acid) in water is investigated. The effectsof the concentration and structure of biobased solvents on the solubilityof phenolic compounds in aqueous solutions at (303.2 & PLUSMN; 0.5) Kwere studied. The results showed that the aqueous solubility of thephenolic compounds studied typically increased with the log (K (OW)) of the hydrotrope (1,2-propanediol <Cyrene < 1,5-pentanediol < GVL < ethyl lactate < 1,6-hexanediol)and the hydrophobicity of the solute; the hydrotropic dissolutionof phenolic compounds is shown to depend on both the hydrotrope andthe solute. This study shows that some biobased solvents, especiallyGVL, are excellent hydrotropes. Their renewable nature, low price,and low toxicity make these results particularly relevant to the fieldof extraction and separation of bioactive compounds.
Language:
English
Type (Professor's evaluation):
Scientific
No. of pages:
8