Propargylamine: an important moiety in drug discovery

• Type: Another Publication in an International Scientific Journal
• Date: 2023

Authors

Carneiro, A (Author) Other; Uriarte, E (Author) Other; Fernanda Borges (Author) FCUP; Matos, MJ (Author) FCUP

Journal

Title: Future Medicinal Chemistry

Vol. 15

Pages: 211-224

ISSN: 1756-8919

Publisher: Future Medicine Ltd.

Indexing

ISI Web of Knowledge - 3 Citations

Scopus

Other information

Authenticus ID: P-00Y-43C

DOI: 10.4155/fmc-2022-0243

Abstract (EN): Propargylamine is a chemical moiety whose properties have made it a widely distributed group within the fields of medicinal chemistry and chemical biology. Its particular reactivity has traditionally popularized the preparation of propargylamine derivatives using a large variety of synthetic strategies, which have facilitated the access to these compounds for the study of their biomedical potential. This review comprehensively covers and analyzes the applications that propargylamine-based derivatives have achieved in the drug discovery field, both from a medicinal chemistry perspective and from a chemical biology-oriented approach. The principal therapeutic fields where propargylamine-based compounds have made an impact are identified, and a discussion of their influence and growing potential is included. Tweetable abstractPropargylamine derivatives are commonly present in various areas of #drugdiscovery. In this new @fsgfmc review article, scientists @aitorcarneiro and @mariacmatos from @UPorto and @UniversidadeUSC discuss the reasons underlying recent uses and applications of these compounds.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 14