Thiocoumarins: From the Synthesis to the Biological Applications

• Type: Another Publication in an International Scientific Journal
• Date: 2022

Authors

Matos, MJ (Author) FCUP; Santana, L (Author) Other; Uriarte, E (Author) Other; Fernanda Borges (Author) FCUP

Journal

Title: Molecules

Serial No. 3 Vol. 27 No. 969

Final page: 4901

ISSN: 1420-3049

Publisher: MDPI

Indexing

ISI Web of Knowledge - 3 Citations

Scopus

Other information

Authenticus ID: P-00X-2JC

DOI: 10.3390/molecules27154901

Abstract (EN): Coumarin is a privilege scaffold in medicinal chemistry. Coumarin derivatives are still an emerging class of highly potent pharmaceutical drugs, best known in the field of antimicrobials and anticoagulants. Thiocoumarins are a particular class of coumarins in which one or two of the oxygen atoms are replaced by a sulfur. They are chemically subdivided in three groups: Thiocoumarins, 2-thioxocoumarins, and dithiocoumarins. This review emphasizes the rationale behind the synthesis and biological applications of the most relevant publications related to this family of compounds. Particular attention has been given to their potential as drug candidates, with particular emphasis in the last 5 years. This article is based on the most relevant information collected from multiple electronic databases, including SciFinder, Pubmed, Espacenet, and Mendeley.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10