The inflammasome in host response to biomaterials: Bridging inflammation and tissue regeneration

• Type: Another Publication in an International Scientific Journal
• Date: 2019

Authors

Vasconcelos, DP (Author) Other; AP Águas (Author) ICBAS; Barbosa, MA (Author) Other; Pelegrin, P (Author) Other; Judite N Barbosa (Author) ICBAS

Journal

Title: Acta Biomaterialia

Vol. 83

Pages: 1-12

ISSN: 1742-7061

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 6 Citations

Scopus - 0 Citations

Other information

Authenticus ID: P-00P-PXV

DOI: 10.1016/j.actbio.2018.09.056

Abstract (EN): The development of new biomaterials to be used in tissue engineering applications is creating new solutions for a range of healthcare problems. The trend in biomaterials research has shifted from biocompatible "immune-evasive" biomaterials to "immune-interactive" materials that modulate the inflammatory response supporting implant integration as well as improving healing and tissue regeneration. Inflammasomes are large intracellular multiprotein complexes that are key players in host defence during innate immune responses and assemble after recognition of pathogens or danger signals. The process of biomaterial implantation causes injury to tissues that will consequently release danger signals that could be sensed by the inflammasome. There are increasing evidences that the inflammasome has a role in several inflammatory processes, from pathogen clearance to chronic inflammation or tissue repair. Thus, modulation of the inflammasome activity appears as an important target in the development of effective approaches in regenerative medicine. In this review, we discuss the main points of the current understanding on the host response to implanted biomaterials and how the paradigm of "immune-evasive" biomaterials has shifted over the last years; the significance of the inflammasome in the inflammatory response to biomaterials; and the growing idea that the immune system is of key importance in an effective tissue repair and regeneration.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 12