Polygenic hazard score is associated with prostate cancer in multi-ethnic populations

• Type: Article in International Scientific Journal
• Date: 2021

Authors

Huynh Le, MP (Author) Other; Fan, CC (Author) Other; Karunamuni, R (Author) Other; Thompson, WK (Author) Other; Martinez, ME (Author) Other; Eeles, RA (Author) Other; Kote Jarai, Z (Author) Other; Muir, K (Author) Other; Schleutker, J (Author) Other; Pashayan, N (Author) Other; Batra, J (Author) Other; Gronberg, H (Author) Other; Neal, DE (Author) Other; Donovan, JL (Author) Other; Hamdy, FC (Author) Other; Martin, RM (Author) Other; Nielsen, SF (Author) Other; Nordestgaard, BG (Author) Other; Wiklund, F (Author) Other; Tangen, CM (Author) Other; Giles, GG (Author) Other; Wolk, A (Author) Other; Albanes, D (Author) Other; Travis, RC (Author) Other; Blot, WJ (Author) Other; Zheng, W (Author) Other; Sanderson, M (Author) Other; Stanford, JL (Author) Other; Mucci, LA (Author) Other; West, CML (Author) Other; Kibel, AS (Author) Other; Cussenot, O (Author) Other; Berndt, SI (Author) Other; Koutros, S (Author) Other; Sorensen, KD (Author) Other; Cybulski, C (Author) Other; Grindedal, EM (Author) Other; Menegaux, F (Author) Other; Khaw, KT (Author) Other; Park, JY (Author) Other; Ingles, SA (Author) Other; Maier, C (Author) Other; Hamilton, RJ (Author) Other; Thibodeau, SN (Author) Other; Rosenstein, BS (Author) Other; Lu, YJ (Author) Other; Watya, S (Author) Other; Vega, A (Author) Other; Kogevinas, M (Author) Other; Penney, KL (Author) Other; Huff, C (Author) Other; Manuel R Teixeira (Author) ICBAS; Multigner, L (Author) Other; Leach, RJ (Author) Other; Cannon Albright, L (Author) Other; Brenner, H (Author) Other; John, EM (Author) Other; Kaneva, R (Author) Other; Logothetis, CJ (Author) Other; Neuhausen, SL (Author) Other; De Ruyck, K (Author) Other; Pandha, H (Author) Other; Razack, A (Author) Other; Newcomb, LF (Author) Other; Fowke, JH (Author) Other; Gamulin, M (Author) Other; Usmani, N (Author) Other; Claessens, F (Author) Other; Gago Dominguez, M (Author) Other; Townsend, PA (Author) Other; Bush, WS (Author) Other; Roobol, MJ (Author) Other; Parent, ME (Author) Other; Hu, JJ (Author) Other; Mills, IG (Author) Other; Andreassen, OA (Author) Other; Dale, AM (Author) Other; Seibert, TM (Author) Other

Journal

Title: Nature Communications

Vol. 12

ISSN: 2041-1723

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 14 Citations

Scopus - 12 Citations

Other information

Authenticus ID: P-00T-JRC

DOI: 10.1038/s41467-021-21287-0

Abstract (EN): Genetic models for cancer have been evaluated using almost exclusively European data, which could exacerbate health disparities. A polygenic hazard score (PHS1) is associated with age at prostate cancer diagnosis and improves screening accuracy in Europeans. Here, we evaluate performance of PHS2 (PHS1, adapted for OncoArray) in a multi-ethnic dataset of 80,491 men (49,916 cases, 30,575 controls). PHS2 is associated with age at diagnosis of any and aggressive (Gleason score >= 7, stage T3-T4, PSA >= 10ng/mL, or nodal/distant metastasis) cancer and prostate-cancer-specific death. Associations with cancer are significant within European (n=71,856), Asian (n=2,382), and African (n=6,253) genetic ancestries (p<10(-180)). Comparing the 80(th)/20(th) PHS2 percentiles, hazard ratios for prostate cancer, aggressive cancer, and prostate-cancer-specific death are 5.32, 5.88, and 5.68, respectively. Within European, Asian, and African ancestries, hazard ratios for prostate cancer are: 5.54, 4.49, and 2.54, respectively. PHS2 risk-stratifies men for any, aggressive, and fatal prostate cancer in a multi-ethnic dataset. A polygenic hazard score (PHS1) improves prostate cancer screening accuracy in European patients. Here, the authors test the performance of a version compatible with OncoArray genotypes (PHS2) in a multi-ethnic dataset and find that it risk-stratifies men for any, aggressive, and fatal prostate cancer.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9