No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer

• Type: Another Publication in an International Scientific Journal
• Date: 2016

Authors

Hollestelle, A (Author) Other; Van Der Baan, FH (Author) Other; Berchuck, A (Author) Other; Johnatty, SE (Author) Other; Aben, KK (Author) Other; Agnarsson, BA (Author) Other; Aittomäki, K (Author) Other; Alducci, E (Author) Other; Andrulis, IL (Author) Other; Anton Culver, H (Author) Other; Antonenkova, NN (Author) Other; Antoniou, AC (Author) Other; Apicella, C (Author) Other; Arndt, V (Author) Other; Arnold, N (Author) Other; Arun, BK (Author) Other; Arver, B (Author) Other; Ashworth, A (Author) Other; Baglietto, L (Author) Other; Balleine, R (Author) Other; Bandera, EV (Author) Other; Barrowdale, D (Author) Other; Bean, YT (Author) Other; Beckmann, L (Author) Other; Beckmann, MW (Author) Other; Benitez, J (Author) Other; Berger, A (Author) Other; Berger, R (Author) Other; Beuselinck, B (Author) Other; Bisogna, M (Author) Other; Bjorge, L (Author) Other; Blomqvist, C (Author) Other; Bogdanova, NV (Author) Other; Bojesen, A (Author) Other; Bojesen, SE (Author) Other; Bolla, MK (Author) Other; Bonanni, B (Author) Other; Brand, JS (Author) Other; Brauch, H (Author) Other; Brenner, H (Author) Other; Brinton, L (Author) Other; Brooks Wilson, A (Author) Other; Bruinsma, F (Author) Other; Brunet, J (Author) Other; Brüning, T (Author) Other; Budzilowska, A (Author) Other; Bunker, CH (Author) Other; Burwinkel, B (Author) Other; Butzow, R (Author) Other; Buys, SS (Author) Other; Caligo, MA (Author) Other; Campbell, I (Author) Other; Carter, J (Author) Other; Chang Claude, J (Author) Other; Chanock, SJ (Author) Other; Claes, KBM (Author) Other; Collée, JM (Author) Other; Cook, LS (Author) Other; Couch, FJ (Author) Other; Cox, A (Author) Other; Cramer, D (Author) Other; Cross, SS (Author) Other; Cunningham, JM (Author) Other; Cybulski, C (Author) Other; Czene, K (Author) Other; Damiola, F (Author) Other; Dansonka Mieszkowska, A (Author) Other; Darabi, H (Author) Other; De La Hoya, M (Author) Other; Defazio, A (Author) Other; Dennis, J (Author) Other; Devilee, P (Author) Other; Dicks, EM (Author) Other; Diez, O (Author) Other; Doherty, JA (Author) Other; Domchek, SM (Author) Other; Dorfling, CM (Author) Other; Dörk, T (Author) Other; Silva, IDS (Author) Other; Du Bois, A (Author) Other; Dumont, M (Author) Other; Dunning, AM (Author) Other; Duran, M (Author) Other; Easton, DF (Author) Other; Eccles, D (Author) Other; Edwards, RP (Author) Other; Ehrencrona, H (Author) Other; Ejlertsen, B (Author) Other; Ekici, AB (Author) Other; Ellis, SD (Author) Other; Engel, C (Author) Other; Eriksson, M (Author) Other; Fasching, PA (Author) Other; Feliubadalo, L (Author) Other; Figueroa, J (Author) Other; Flesch Janys, D (Author) Other; Fletcher, O (Author) Other; Fontaine, A (Author) Other; Fortuzzi, S (Author) Other; Fostira, F (Author) Other; Fridley, BL (Author) Other; Friebel, T (Author) Other; Friedman, E (Author) Other; Friel, G (Author) Other; Frost, D (Author) Other; Garber, J (Author) Other; García Closas, M (Author) Other; Gayther, SA (Author) Other; Gentry Maharaj, A (Author) Other; Gerdes, AM (Author) Other; Giles, GG (Author) Other; Glasspool, R (Author) Other; Glendon, G (Author) Other; Godwin, AK (Author) Other; Goodman, MT (Author) Other; Gore, M (Author) Other; Greene, MH (Author) Other; Grip, M (Author) Other; Gronwald, J (Author) Other; Gschwantler Kaulich, D (Author) Other; Guénel, P (Author) Other; Guzman, SR (Author) Other; Haeberle, L (Author) Other; Haiman, CA (Author) Other; Hall, P (Author) Other; Halverson, SL (Author) Other; Hamann, U (Author) Other; Hansen, TVO (Author) Other; Harter, P (Author) Other; Hartikainen, JM (Author) Other; Healey, S (Author) Other; Hein, A (Author) Other; Heitz, F (Author) Other; Henderson, BE (Author) Other; Herzog, J (Author) Other; T Hildebrandt, MA (Author) Other; Høgdall, CK (Author) Other; Høgdall, E (Author) Other; Hogervorst, FBL (Author) Other; Hopper, JL (Author) Other; Humphreys, K (Author) Other; Huzarski, T (Author) Other; Imyanitov, EN (Author) Other; Isaacs, C (Author) Other; Jakubowska, A (Author) Other; Janavicius, R (Author) Other; Jaworska, K (Author) Other; Jensen, A (Author) Other; Jensen, UB (Author) Other; Johnson, N (Author) Other; Jukkola Vuorinen, A (Author) Other; Kabisch, M (Author) Other; Karlan, BY (Author) Other; Kataja, V (Author) Other; Kauff, N (Author) Other; Kelemen, LE (Author) Other; Kerin, MJ (Author) Other; Kiemeney, LA (Author) Other; Kjaer, SK (Author) Other; Knight, JA (Author) Other; Knol Bout, JP (Author) Other; Konstantopoulou, I (Author) Other; Kosma, VM (Author) Other; Krakstad, C (Author) Other; Kristensen, V (Author) Other; Kuchenbaecker, KB (Author) Other; Kupryjanczyk, J (Author) Other; Laitman, Y (Author) Other; Lambrechts, D (Author) Other; Lambrechts, S (Author) Other; Larson, MC (Author) Other; Lasa, A (Author) Other; Laurent Puig, P (Author) Other; Lazaro, C (Author) Other; Le, ND (Author) Other; Le Marchand, L (Author) Other; Leminen, A (Author) Other; Lester, J (Author) Other; Levine, DA (Author) Other; Li, J (Author) Other; Liang, D (Author) Other; Lindblom, A (Author) Other; Lindor, N (Author) Other; Lissowska, J (Author) Other; Long, J (Author) Other; Lu, KH (Author) Other; Lubinski, J (Author) Other; Lundvall, L (Author) Other; Lurie, G (Author) Other; Mai, PL (Author) Other; Mannermaa, A (Author) Other; Margolin, S (Author) Other; Mariette, F (Author) Other; Marme, F (Author) Other; Martens, JWM (Author) Other; Massuger, LFAG (Author) Other; Maugard, C (Author) Other; Mazoyer, S (Author) Other; McGuffog, L (Author) Other; McGuire, V (Author) Other; McLean, C (Author) Other; McNeish, I (Author) Other; Meindl, A (Author) Other; Menegaux, F (Author) Other; Menéndez, P (Author) Other; Menkiszak, J (Author) Other; Menon, U (Author) Other; Mensenkamp, AR (Author) Other; Miller, N (Author) Other; Milne, RL (Author) Other; Modugno, F (Author) Other; Montagna, M (Author) Other; Moysich, KB (Author) Other; Müller, H (Author) Other; Mulligan, AM (Author) Other; Muranen, TA (Author) Other; Narod, SA (Author) Other; Nathanson, KL (Author) Other; Ness, RB (Author) Other; Neuhausen, SL (Author) Other; Nevanlinna, H (Author) Other; Neven, P (Author) Other; Nielsen, FC (Author) Other; Nielsen, SF (Author) Other; Nordestgaard, BG (Author) Other; Nussbaum, RL (Author) Other; Odunsi, K (Author) Other; Offit, K (Author) Other; Olah, E (Author) Other; Olopade, OI (Author) Other; Olson, JE (Author) Other; Olson, SH (Author) Other; Oosterwijk, JC (Author) Other; Orlow, I (Author) Other; Orr, N (Author) Other; Orsulic, S (Author) Other; Osorio, A (Author) Other; Ottini, L (Author) Other; Paul, J (Author) Other; Pearce, CL (Author) Other; Pedersen, IS (Author) Other; Peissel, B (Author) Other; Pejovic, T (Author) Other; Pelttari, LM (Author) Other; Perkins, J (Author) Other; Permuth Wey, J (Author) Other; Peterlongo, P (Author) Other; Peto, J (Author) Other; Phelan, CM (Author) Other; Phillips, KA (Author) Other; Piedmonte, M (Author) Other; Pike, MC (Author) Other; Platte, R (Author) Other; Plisiecka Halasa, J (Author) Other; Poole, EM (Author) Other; Poppe, B (Author) Other; Pylkäs, K (Author) Other; Radice, P (Author) Other; Ramus, SJ (Author) Other; Rebbeck, TR (Author) Other; Reed, MWR (Author) Other; Rennert, G (Author) Other; Risch, HA (Author) Other; Robson, M (Author) Other; Rodriguez, GC (Author) Other; Romero, A (Author) Other; Rossing, MA (Author) Other; Rothstein, JH (Author) Other; Rudolph, A (Author) Other; Runnebaum, I (Author) Other; Salani, R (Author) Other; Salvesen, HB (Author) Other; Sawyer, EJ (Author) Other; Schildkraut, JM (Author) Other; Schmidt, MK (Author) Other; Schmutzler, RK (Author) Other; Schneeweiss, A (Author) Other; Schoemaker, MJ (Author) Other; Schrauder, MG (Author) Other; Schumacher, F (Author) Other; Schwaab, I (Author) Other; Scuvera, G (Author) Other; Sellers, TA (Author) Other; Severi, G (Author) Other; Seynaeve, CM (Author) Other; Shah, M (Author) Other; Shrubsole, M (Author) Other; Siddiqui, N (Author) Other; Sieh, W (Author) Other; Simard, J (Author) Other; Singer, CF (Author) Other; Sinilnikova, OM (Author) Other; Smeets, D (Author) Other; Sohn, C (Author) Other; Soller, M (Author) Other; Song, H (Author) Other; Soucy, P (Author) Other; Southey, MC (Author) Other; Stegmaier, C (Author) Other; Stoppa Lyonnet, D (Author) Other; Sucheston, L (Author) Other; Swerdlow, A (Author) Other; Tangen, IL (Author) Other; Tea, MK (Author) Other; Manuel R Teixeira (Author) ICBAS; Terry, KL (Author) Other; Terry, MB (Author) Other; Thomassen, M (Author) Other; Thompson, PJ (Author) Other; Tihomirova, L (Author) Other; Tischkowitz, M (Author) Other; Toland, AE (Author) Other; Tollenaar, RAEM (Author) Other; Tomlinson, I (Author) Other; Torres, D (Author) Other; Truong, T (Author) Other; Tsimiklis, H (Author) Other; Tung, N (Author) Other; Tworoger, SS (Author) Other; Tyrer, JP (Author) Other; Vachon, CM (Author) Other; Van 't Veer, LJ (Author) Other; Van Altena, AM (Author) Other; Van Asperen, CJ (Author) Other; Van Den Berg, D (Author) Other; Van Den Ouweland, AMW (Author) Other; Van Doorn, HC (Author) Other; Van Nieuwenhuysen, E (Author) Other; Van Rensburg, EJ (Author) Other; Vergote, I (Author) Other; Verhoef, S (Author) Other; Vierkant, RA (Author) Other; Vijai, J (Author) Other; Vitonis, AF (Author) Other; Von Wachenfeldt, A (Author) Other; Walsh, C (Author) Other; Wang, Q (Author) Other; Wang Gohrke, S (Author) Other; Wappenschmidt, B (Author) Other; Weischer, M (Author) Other; Weitzel, JN (Author) Other; Weltens, C (Author) Other; Wentzensen, N (Author) Other; Whittemore, AS (Author) Other; Wilkens, LR (Author) Other; Winqvist, R (Author) Other; Wu, AH (Author) Other; Wu, X (Author) Other; Yang, HP (Author) Other; Zaffaroni, D (Author) Other; Pilar Zamora, M (Author) Other; Zheng, W (Author) Other; Ziogas, A (Author) Other; Chenevix Trench, G (Author) Other; Pharoah, PDP (Author) Other; Rookus, MA (Author) Other; Hooning, MJ (Author) Other; Goode, EL (Author) Other; Breast Cancer Family Register, (Author) Other; EMBRACE, (Author) Other; GENICA Network, (Author) Other; HEBON, (Author) Other; SWE BRCA, (Author) Other

Journal

Title: Gynecologic Oncology

Vol. 141

Pages: 386-401

ISSN: 0090-8258

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 9 Citations

Scopus - 11 Citations

Other information

Authenticus ID: P-00K-E7A

DOI: 10.1016/j.ygyno.2015.04.034

Abstract (EN): Objective. Clinical genetic testing is commercially available for rs61764370, an inherited variant residing in a KRAS 3' UTR microRNA binding site, based on suggested associations with increased ovarian and breast cancer risk as well as with survival time. However, prior studies, emphasizing particular subgroups, were relatively small. Therefore, we comprehensively evaluated ovarian and breast cancer risks as well as clinical outcome associated with rs61764370. Methods. Centralized genotyping and analysis were performed for 140,012 women enrolled in the Ovarian Cancer Association Consortium (15,357 ovarian cancer patients; 30,816 controls), the Breast Cancer Association Consortium (33,530 breast cancer patients; 37,640 controls), and the Consortium of Modifiers of BRCA1 and BRCA2 (14,765 BRCA1 and 7904 BRCA2 mutation carriers). Results. We found no association with risk of ovarian cancer (OR = 0.99, 95% CI 0.94-1.04, p = 0.74) or breast cancer (OR = 0.98, 95% CI 0.94-1.01, p = 0.19) and results were consistent among mutation carriers (BRCA1, ovarian cancer HR = 1.09, 95% CI 0.97-1.23, p = 0.14, breast cancer HR = 1.04, 95% CI 0.97-1.12, p = 0.27; BRCA2, ovarian cancer HR = 0.89, 95% CI 0.71-1.13, p = 034, breast cancer HR = 1.06, 95% CI 0.94-1.19, p = 0.35). Null results were also obtained for associations with overall survival following ovarian cancer (HR = 0.94, 95% CI 0.83-1.07, p = 0.38), breast cancer (HR = 0.96, 95% CI 0.87-1.06, p = 0.38), and all other previously-reported associations. Conclusions. rs61764370 is not associated with risk of ovarian or breast cancer nor with clinical outcome for patients with these cancers. Therefore, genotyping this variant has no clinical utility related to the prediction or management of these cancers.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 16