The Helicobacter pylori Genome Project: insights into H. pylori population structure from analysis of a worldwide collection of complete genomes

• Type: Article in International Scientific Journal
• Date: 2023

Authors

Thorell, K (Author) Other; Muñoz Ramírez, ZY (Author) Other; Wang, D (Author) Other; Sandoval Motta, S (Author) Other; Boscolo Agostini, R (Author) Other; Ghirotto, S (Author) Other; Torres, RC (Author) Other; Romero Gallo, J (Author) Other; Krishna, U (Author) Other; Peek, RM (Author) Other; Piazuelo, MB (Author) Other; Raaf, N (Author) Other; Bentolila, F (Author) Other; Aftab, H (Author) Other; Akada, J (Author) Other; Matsumoto, T (Author) Other; Haesebrouck, F (Author) Other; Colanzi, RP (Author) Other; Bartelli, TF (Author) Other; Nunes, DN (Author) Other; Pelosof, A (Author) Other; Sztokfisz, CZ (Author) Other; Dias Neto, E (Author) Other; Assumpção, PP (Author) Other; Tishkov, I (Author) Other; Mabeku, LBK (Author) Other; Goodman, KJ (Author) Other; Geary, J (Author) Other; Cromarty, TJ (Author) Other; Price, NL (Author) Other; Quilty, D (Author) Other; Corvalan, AH (Author) Other; Serrano, CA (Author) Other; Gonzalez, R (Author) Other; Riquelme, A (Author) Other; García Cancino, A (Author) Other; Parra Sepúlveda, C (Author) Other; Bernal, G (Author) Other; Castillo, F (Author) Other; Goldstein, AM (Author) Other; Hu, N (Author) Other; Taylor, PR (Author) Other; Bravo, MM (Author) Other; Pazos, A (Author) Other; Bravo, LE (Author) Other; Wilson, KT (Author) Other; Fox, JG (Author) Other; Ramírez Mayorga, V (Author) Other; Molina Castro, S (Author) Other; Durán Bermúdez, S (Author) Other; Campos Núñez, C (Author) Other; Chaves Cervantes, M (Author) Other; Tshibangu Kabamba, E (Author) Other; Tumba, GD (Author) Other; Tshimpi Wola, A (Author) Other; de Jesus Ngoma Kisoko, P (Author) Other; Ngoyi, DM (Author) Other; Cruz, M (Author) Other; Hosking, C (Author) Other; Abreu, JJ (Author) Other; Varon, C (Author) Other; Benejat, L (Author) Other; Secka, O (Author) Other; Link, A (Author) Other; Malfertheiner, P (Author) Other; Adinortey, MB (Author) Other; Bockarie, AS (Author) Other; Adinortey, CA (Author) Other; Ofori, EG (Author) Other; Sgouras, DN (Author) Other; Martinez Gonzalez, B (Author) Other; Michopoulos, S (Author) Other; Georgopoulos, S (Author) Other; Hernandez, E (Author) Other; Tacatic, BV (Author) Other; Aguilar, M (Author) Other; Dominguez, RL (Author) Other; Morgan, DR (Author) Other; Harðardóttir, H (Author) Other; Gunnarsdóttir, AI (Author) Other; Guðjónsson, H (Author) Other; Jónasson, JG (Author) Other; Björnsson, ES (Author) Other; Ballal, M (Author) Other; Shetty, V (Author) Other; Miftahussurur, M (Author) Other; Sugihartono, T (Author) Other; Alfaray, RI (Author) Other; Waskito, LA (Author) Other; Fauzia, KA (Author) Other; Syam, AF (Author) Other; Maulahela, H (Author) Other; Malekzadeh, R (Author) Other; Sotoudeh, M (Author) Other; Peretz, A (Author) Other; Azrad, M (Author) Other; On, A (Author) Other; De Re, V (Author) Other; Zanussi, S (Author) Other; Cannizzaro, R (Author) Other; Canzonieri, V (Author) Other; Shimura, T (Author) Other; Tokunaga, K (Author) Other; Osaki, T (Author) Other; Kamiya, S (Author) Other; Jadallah, K (Author) Other; Matalka, I (Author) Other; Igissinov, N (Author) Other; Moldobaeva, MS (Author) Other; Rakhat, A (Author) Other; Choi, IJ (Author) Other; Kim, JG (Author) Other; Kim, N (Author) Other; Song, M (Author) Other; Leja, M (Author) Other; Vangravs, R (Author) Other; ¦¿enders, ¿ (Author) Other; Rudz¿te, D (Author) Other; R¿dule, A (Author) Other; Vanags, A (Author) Other; Kikuste, I (Author) Other; Kupcinskas, J (Author) Other; Skieceviciene, J (Author) Other; Jonaitis, L (Author) Other; Kiudelis, G (Author) Other; Jonaitis, P (Author) Other; Kiudelis, V (Author) Other; Varkalaite, G (Author) Other; Vadivelu, J (Author) Other; Loke, MF (Author) Other; Vellasamy, KM (Author) Other; Herrera Goepfert, R (Author) Other; Alonso Larraga, JO (Author) Other; Yee, TT (Author) Other; Htet, K (Author) Other; Matsuhisa, T (Author) Other; Shrestha, PK (Author) Other; Ansari, S (Author) Other; Abiodun, O (Author) Other; Jemilohun, C (Author) Other; Akande, KO (Author) Other; Olu Abiodun, O (Author) Other; Magaji, FA (Author) Other; Omotoso, A (Author) Other; Osuagwu, CC (Author) Other; Okonkwo, U (Author) Other; Owoseni, OO (Author) Other; Castaneda, C (Author) Other; Castillo, M (Author) Other; Velapatino, B (Author) Other; Gilman, RH (Author) Other; Krzy¿ek, P (Author) Other; Go¿ciniak, G (Author) Other; Pawe¿ka, D (Author) Other; Korona Glowniak, I (Author) Other; Cichoz Lach, H (Author) Other; Oleastro, M (Author) Other; Figueiredo C (Author) FMUP; Machado JC (Author) FMUP; Ferreira, RM (Author) Other; Bordin, DS (Author) Other; Livzan, MA (Author) Other; Tsukanov, VV (Author) Other; Tan, P (Author) Other; Yeoh, KG (Author) Other; Zhu, F (Author) Other; Ally, R (Author) Other; Haas, R (Author) Other; Montes, M (Author) Other; Fernández Reyes, M (Author) Other; Tamayo, E (Author) Other; Lizasoain, J (Author) Other; Bujanda, L (Author) Other; Lario, S (Author) Other; Ramírez Lázaro, MJ (Author) Other; Calvet, X (Author) Other; Brunet Mas, E (Author) Other; Domper Arnal, MJ (Author) Other; García Mateo, S (Author) Other; Abad Baroja, D (Author) Other; Delgado Guillena, P (Author) Other; Moreira, L (Author) Other; Botargues, J (Author) Other; Pérez Martínez, I (Author) Other; Barreiro Alonso, E (Author) Other; Flores, V (Author) Other; Gisbert, JP (Author) Other; Muro, EA (Author) Other; Linares, P (Author) Other; Martin, V (Author) Other; Alcoba, L (Author) Other; Fleitas Kanonnikoff, T (Author) Other; Altayeb, HN (Author) Other; Engstrand, L (Author) Other; Enroth, H (Author) Other; Keller, PM (Author) Other; Wagner, K (Author) Other; Pohl, D (Author) Other; Lee, Y (Author) Other; Liou, J (Author) Other; Wu, M (Author) Other; Kocazeybek, B (Author) Other; Sar¿bas, S (Author) Other; Tasç¿, ¿ (Author) Other; Demiryas, S (Author) Other; Kepil, N (Author) Other; Quiel, L (Author) Other; Villagra, M (Author) Other; Norton, M (Author) Other; Johnson, D (Author) Other; Huang, RJ (Author) Other; Hwang, JH (Author) Other; Szymczak, W (Author) Other; Rajagopalan, S (Author) Other; Asare, E (Author) Other; Jacobs, WR (Author) Other; In, H (Author) Other; Bollag, R (Author) Other; Lopez, A (Author) Other; Kruse, EJ (Author) Other; White, J (Author) Other; Graham, DY (Author) Other; Lane, C (Author) Other; Gao, Y (Author) Other; Fields, PI (Author) Other; Gold, BD (Author) Other; Cruz Correa, M (Author) Other; González Pons, M (Author) Other; Rodriguez, LM (Author) Other; Tuan, VP (Author) Other; Dung, HDQ (Author) Other; Binh, TT (Author) Other; Trang, TTH (Author) Other; Van Khien, V (Author) Other; Chen, X (Author) Other; Raley, C (Author) Other; Kessing, B (Author) Other; Zhao, Y (Author) Other; Tran, B (Author) Other; Gutiérrez Escobar, AJ (Author) Other; Wan, Y (Author) Other; Hicks, B (Author) Other; Zhu, B (Author) Other; Yu, K (Author) Other; Zhu, B (Author) Other; Yeager, M (Author) Other; Hutchinson, A (Author) Other; Teshome, K (Author) Other; Jones, K (Author) Other; Luo, W (Author) Other; Jehanne, Q (Author) Other; Katsura, Y (Author) Other; Gonzalez Hormazabal, P (Author) Other; Didelot, X (Author) Other; Sheppard, S (Author) Other; Tarazona Santos, E (Author) Other; Mariño Ramírez, L (Author) Other; Loh, JT (Author) Other; Backert, S (Author) Other; Naumann, M (Author) Other; Abnet, CC (Author) Other; Smet, A (Author) Other; Berg, DE (Author) Other; Chiner Oms, Á (Author) Other; Comas, I (Author) Other; Martínez Martínez, FJ (Author) Other; Zamudio, R (Author) Other; Lehours, P (Author) Other; Megraud, F (Author) Other; Yahara, K (Author) Other; Blaser, MJ (Author) Other; Vincze, T (Author) Other; Morgan, RD (Author) Other; Roberts, RJ (Author) Other; Chanock, SJ (Author) Other; Dekker, JP (Author) Other; Torres, J (Author) Other; Cover, TL (Author) Other; Noureen, M (Author) Other; Fischer, W (Author) Other; Vale, FF (Author) Other; Cherry, JL (Author) Other; Osada, N (Author) Other; Fukuyo, M (Author) Other; Arita, M (Author) Other; Yamaoka, Y (Author) Other; Kobayashi, I (Author) Other; Uchiyama, I (Author) Other; Falush, D (Author) Other; Camargo, MC (Author) Other; Rabkin, CS (Author) Other

Journal

Title: Nature Communications

Vol. 14

ISSN: 2041-1723

Publisher: Springer Nature

Indexing

Scopus - 0 Citations

Other information

Authenticus ID: P-00Z-GTM

DOI: 10.1038/s41467-023-43562-y

Abstract (EN): Helicobacter pylori, a dominant member of the gastric microbiota, shares co-evolutionary history with humans. This has led to the development of genetically distinct H. pylori subpopulations associated with the geographic origin of the host and with differential gastric disease risk. Here, we provide insights into H. pylori population structure as a part of the Helicobacter pylori Genome Project (HpGP), a multi-disciplinary initiative aimed at elucidating H. pylori pathogenesis and identifying new therapeutic targets. We collected 1011 well-characterized clinical strains from 50 countries and generated high-quality genome sequences. We analysed core genome diversity and population structure of the HpGP dataset and 255 worldwide reference genomes to outline the ancestral contribution to Eurasian, African, and American populations. We found evidence of substantial contribution of population hpNorthAsia and subpopulation hspUral in Northern European H. pylori. The genomes of H. pylori isolated from northern and southern Indigenous Americans differed in that bacteria isolated in northern Indigenous communities were more similar to North Asian H. pylori while the southern had higher relatedness to hpEastAsia. Notably, we also found a highly clonal yet geographically dispersed North American subpopulation, which is negative for the cag pathogenicity island, and present in 7% of sequenced US genomes. We expect the HpGP dataset and the corresponding strains to become a major asset for H. pylori genomics.

Language: English

Type (Professor's evaluation): Scientific