Neuroendocrine pathways at risk? Simvastatin induces inter and transgenerational disruption in the keystone amphipod Gammarus locusta

• Type: Article in International Scientific Journal
• Date: 2022

Authors

Neuparth, T (Author) Other; Alves, N (Author) Other; Machado, AM (Author) Other; Pinheiro, M (Author) Other; Montes, R (Author) Other; Rodil, R (Author) Other; Barros, S (Author) Other; Ruivo, R (Author) Other; Filipe F C Castro (Author) FCUP; Quintana, JB (Author) Other; Santos, MM (Author) FCUP

Journal

Title: Aquatic Toxicology

Vol. 244

ISSN: 0166-445X

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 4 Citations

Scopus - 4 Citations

Other information

Authenticus ID: P-00W-1QD

DOI: 10.1016/j.aquatox.2022.106095

Abstract (EN): The primary focus of environmental toxicological studies is to address the direct effects of chemicals on exposed organisms (parental generation - F0), mostly overlooking effects on subsequent non-exposed generations (F1 and F2 - intergenerational and F3 transgenerational, respectively). Here, we addressed the effects of simvastatin (SIM), one of the most widely prescribed human pharmaceuticals for the primary treatment of hypercholesterolemia, using the keystone crustacean Gammarus locusta. We demonstrate that SIM, at environmentally relevant concentrations, has significant inter and transgenerational (F1 and F3) effects in key signaling pathways involved in crustaceans' neumendocrine regulation (Ecdystemids, Catecholamines, NO/cGMP/PKG, GABAergic and Cholinergic signaling pathways), concomitantly with changes in apical endpoints, such as depressed reproduction and growth. These findings are an essential step to improve hazard and risk assessment of biological active compounds, such as SIM, and highlight the importance of studying the transgenerational effects of environmental chemicals in animals' neuroendocrine regulation.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 17